Altered vascular contractility in adult female rats with hypertension programmed by prenatal glucocorticoid exposure

Excessive exposure to glucocorticoids during gestation reduces birth weight and induces permanent hypertension in adulthood. The mechanisms underlying this programmed elevation of blood pressure have not been established. We hypothesised that prenatal glucocorticoid exposure may lead to vascular dys...

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Veröffentlicht in:	Journal of endocrinology 2006-03, Vol.188 (3), p.435-442
Hauptverfasser:	Hadoke, P W F, Lindsay, R S, Seckl, J R, Walker, B R, Kenyon, C J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Aldosterone - blood Angiotensin II - pharmacology Animals Animals, Newborn Aorta - drug effects Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Corticosterone - blood Dexamethasone - pharmacology Dose-Response Relationship, Drug Experimental diseases Female Glucocorticoids - pharmacology Hypertension - embryology Hypertension - pathology Hypertension - physiopathology In Vitro Techniques Infusion Pumps Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - pathology Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Regular papers Renin - blood Vasoconstriction - drug effects
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