Tau phosphorylation in Alzheimer's disease: pathogen or protector?

During the past decade, hypotheses concerning the pathogenesis of most neurodegenerative diseases have been dominated by the notion that the aggregation of specific proteins and subsequent formation of cytoplasmic and extracellular lesions represent a harbinger of neuronal dysfunction and death. As...

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Veröffentlicht in:	Trends in molecular medicine 2005-04, Vol.11 (4), p.164-169
Hauptverfasser:	Lee, Hyoung-gon, Perry, George, Moreira, Paula I., Garrett, Matthew R., Liu, Quan, Zhu, Xiongwei, Takeda, Atsushi, Nunomura, Akihiko, Smith, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer Disease - prevention & control Humans Microtubules - physiology Neurofibrillary Tangles - pathology Phosphorylation tau Proteins - metabolism
Online-Zugang:	Volltext
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