Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Is a Marker for Coronary Artery Disease in African-American and Caucasian Men
We investigated the association of the intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD). Genetic alterations in the gene encoding for eNOS could contribute to the development and progression of CAD. We genotyped for the eNOS intron 4 polym...
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| Veröffentlicht in: | Ethnicity & disease 2005-03, Vol.15 (2), p.191-197 |
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| creator | Rao, Swapna Austin, Harland Davidoff, Madalyn N. Zafari, A. Maziar |
| description | We investigated the association of the intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD).
Genetic alterations in the gene encoding for eNOS could contribute to the development and progression of CAD.
We genotyped for the eNOS intron 4 polymorphism in 194 subjects undergoing coronary angiography. Genotyping was performed with polymerase chain reaction-restriction fragment length polymorphism for the variable number of tandem repeats in intron 4. Coronary artery disease (CAD) was assessed by quantitative coronary angiography, and endothelial function was measured by brachial ultrasonography. We performed logistic regression analysis for the effect of eNOS intron 4 polymorphism and other coronary risk factors on multi-vessel CAD and endothelial function.
The 4a-allele frequency in African Americans was 0.31, while the 4a-allele frequency in Caucasians was 0.15 (P |
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Genetic alterations in the gene encoding for eNOS could contribute to the development and progression of CAD.
We genotyped for the eNOS intron 4 polymorphism in 194 subjects undergoing coronary angiography. Genotyping was performed with polymerase chain reaction-restriction fragment length polymorphism for the variable number of tandem repeats in intron 4. Coronary artery disease (CAD) was assessed by quantitative coronary angiography, and endothelial function was measured by brachial ultrasonography. We performed logistic regression analysis for the effect of eNOS intron 4 polymorphism and other coronary risk factors on multi-vessel CAD and endothelial function.
The 4a-allele frequency in African Americans was 0.31, while the 4a-allele frequency in Caucasians was 0.15 (P<.001). The prevalence of the 4a-allele was highest among subjects with multi-vessel disease both for African Americans and for Caucasians. A race-adjusted comparison of the prevalence of the 4a-allele among subjects with multi-vessel disease vs those without was statistically significant (P=.03). No correlation was found between the eNOS intron 4 polymorphism and endothelial function.
The eNOS intron 4 polymorphism may be a marker of multi-vessel CAD in African Americans and Caucasians.</description><identifier>ISSN: 1049-510X</identifier><identifier>PMID: 15825964</identifier><language>eng</language><publisher>United States: Ethnicity & Disease, Inc</publisher><subject>Adult ; African Americans ; African Americans - genetics ; Aged ; Cardiovascular Disease ; Caucasians ; Coronary Artery Disease - enzymology ; Coronary Artery Disease - ethnology ; Coronary Artery Disease - genetics ; European Continental Ancestry Group - genetics ; Genetic Markers - genetics ; Genetics ; Genotype ; Health and Medicine ; Heart attacks ; Humans ; Introns - genetics ; Logistic Models ; Male ; Medical research ; Middle Aged ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Original Reports: Cardiovascular Health ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Risk Factors ; Tandem Repeat Sequences ; United States</subject><ispartof>Ethnicity & disease, 2005-03, Vol.15 (2), p.191-197</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48666319$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48666319$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15825964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Swapna</creatorcontrib><creatorcontrib>Austin, Harland</creatorcontrib><creatorcontrib>Davidoff, Madalyn N.</creatorcontrib><creatorcontrib>Zafari, A. Maziar</creatorcontrib><title>Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Is a Marker for Coronary Artery Disease in African-American and Caucasian Men</title><title>Ethnicity & disease</title><addtitle>Ethn Dis</addtitle><description>We investigated the association of the intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD).
Genetic alterations in the gene encoding for eNOS could contribute to the development and progression of CAD.
We genotyped for the eNOS intron 4 polymorphism in 194 subjects undergoing coronary angiography. Genotyping was performed with polymerase chain reaction-restriction fragment length polymorphism for the variable number of tandem repeats in intron 4. Coronary artery disease (CAD) was assessed by quantitative coronary angiography, and endothelial function was measured by brachial ultrasonography. We performed logistic regression analysis for the effect of eNOS intron 4 polymorphism and other coronary risk factors on multi-vessel CAD and endothelial function.
The 4a-allele frequency in African Americans was 0.31, while the 4a-allele frequency in Caucasians was 0.15 (P<.001). The prevalence of the 4a-allele was highest among subjects with multi-vessel disease both for African Americans and for Caucasians. A race-adjusted comparison of the prevalence of the 4a-allele among subjects with multi-vessel disease vs those without was statistically significant (P=.03). No correlation was found between the eNOS intron 4 polymorphism and endothelial function.
The eNOS intron 4 polymorphism may be a marker of multi-vessel CAD in African Americans and Caucasians.</description><subject>Adult</subject><subject>African Americans</subject><subject>African Americans - genetics</subject><subject>Aged</subject><subject>Cardiovascular Disease</subject><subject>Caucasians</subject><subject>Coronary Artery Disease - enzymology</subject><subject>Coronary Artery Disease - ethnology</subject><subject>Coronary Artery Disease - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genetic Markers - genetics</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Health and Medicine</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Introns - genetics</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Original Reports: Cardiovascular Health</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Risk Factors</subject><subject>Tandem Repeat Sequences</subject><subject>United States</subject><issn>1049-510X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1Kw0AUhbNQbK0-gjIguAtMkvlJliFWLbRWUMFdmCQ3dGIyU2cmYB_A93a01YWrcy_3u4fDOQqmESZZSCP8OglOre0wjikl5CSYRDSNacbINPicq0a7DfRS9OhBOiNrtP6QDaCnnXIbYQEtlDNaIYIedb8btNlupB3QwiKBVsK8gUGtNqjQHhJmh3LjwMuNtPD9LRXKW-8qVJgP8DMgoRpUiLEWVvptBeosOG5Fb-H8oLPg5Xb-XNyHy_XdosiXYefjurChdcVITUgVVzHlgkWYYoEzwjKB64TyDBJgKa8Jz9KY4KrlFLeU4wqqGOo2mQXXe9-t0e8jWFcO0tbQ90KBHm3JOE8wT4gHr_6BnR6N8tnKmKYsTSLOsacuD9RYDdCUWyMHX0H5W68HLvZAZ502f3eSMsaSKEu-AO26fuc</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Rao, Swapna</creator><creator>Austin, Harland</creator><creator>Davidoff, Madalyn N.</creator><creator>Zafari, A. Maziar</creator><general>Ethnicity & Disease, Inc</general><general>International Society on Hypertension in Blacks</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Is a Marker for Coronary Artery Disease in African-American and Caucasian Men</title><author>Rao, Swapna ; Austin, Harland ; Davidoff, Madalyn N. ; Zafari, A. Maziar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j259t-d5cb64c44b2b257a61050a09469a0c3579e3e687c4798240bf750f570beb2ecf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>African Americans - genetics</topic><topic>Aged</topic><topic>Cardiovascular Disease</topic><topic>Caucasians</topic><topic>Coronary Artery Disease - enzymology</topic><topic>Coronary Artery Disease - ethnology</topic><topic>Coronary Artery Disease - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Genetic Markers - genetics</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Health and Medicine</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Introns - genetics</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Original Reports: Cardiovascular Health</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Risk Factors</topic><topic>Tandem Repeat Sequences</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Swapna</creatorcontrib><creatorcontrib>Austin, Harland</creatorcontrib><creatorcontrib>Davidoff, Madalyn N.</creatorcontrib><creatorcontrib>Zafari, A. Maziar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Ethnicity & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Swapna</au><au>Austin, Harland</au><au>Davidoff, Madalyn N.</au><au>Zafari, A. Maziar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Is a Marker for Coronary Artery Disease in African-American and Caucasian Men</atitle><jtitle>Ethnicity & disease</jtitle><addtitle>Ethn Dis</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>15</volume><issue>2</issue><spage>191</spage><epage>197</epage><pages>191-197</pages><issn>1049-510X</issn><abstract>We investigated the association of the intron 4 polymorphism of the endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD).
Genetic alterations in the gene encoding for eNOS could contribute to the development and progression of CAD.
We genotyped for the eNOS intron 4 polymorphism in 194 subjects undergoing coronary angiography. Genotyping was performed with polymerase chain reaction-restriction fragment length polymorphism for the variable number of tandem repeats in intron 4. Coronary artery disease (CAD) was assessed by quantitative coronary angiography, and endothelial function was measured by brachial ultrasonography. We performed logistic regression analysis for the effect of eNOS intron 4 polymorphism and other coronary risk factors on multi-vessel CAD and endothelial function.
The 4a-allele frequency in African Americans was 0.31, while the 4a-allele frequency in Caucasians was 0.15 (P<.001). The prevalence of the 4a-allele was highest among subjects with multi-vessel disease both for African Americans and for Caucasians. A race-adjusted comparison of the prevalence of the 4a-allele among subjects with multi-vessel disease vs those without was statistically significant (P=.03). No correlation was found between the eNOS intron 4 polymorphism and endothelial function.
The eNOS intron 4 polymorphism may be a marker of multi-vessel CAD in African Americans and Caucasians.</abstract><cop>United States</cop><pub>Ethnicity & Disease, Inc</pub><pmid>15825964</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adult African Americans African Americans - genetics Aged Cardiovascular Disease Caucasians Coronary Artery Disease - enzymology Coronary Artery Disease - ethnology Coronary Artery Disease - genetics European Continental Ancestry Group - genetics Genetic Markers - genetics Genetics Genotype Health and Medicine Heart attacks Humans Introns - genetics Logistic Models Male Medical research Middle Aged Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Original Reports: Cardiovascular Health Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Risk Factors Tandem Repeat Sequences United States |
| title | Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Is a Marker for Coronary Artery Disease in African-American and Caucasian Men |
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