Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats
To investigate the effects of fermented brown rice (FBRA) on the development of hereditary hepatitis in Long-Evans Cinnamon (LEC) rats, we compared the incidence and grades of acute hepatitis among rats fed 5% and 10% FBRA in the conventional diet and the conventional diet alone. Both the 5% and 10%...
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| Veröffentlicht in: | Oncology reports 2006-04, Vol.15 (4), p.869-874 |
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| creator | SHIBATA, Toshiyuki NAGAYASU, Hiroki KITAJO, Hiroyuki ARISUE, Makoto YAMASHITA, Tomomi HATAKEYAMA, Daijiro IWASAKI, Teruaki KOBAYASHI, Hiroshi |
| description | To investigate the effects of fermented brown rice (FBRA) on the development of hereditary hepatitis in Long-Evans Cinnamon (LEC) rats, we compared the incidence and grades of acute hepatitis among rats fed 5% and 10% FBRA in the conventional diet and the conventional diet alone. Both the 5% and 10% FBRA-supplemented diets indicated a tendency to prevent the development of hepatitis, and the significant effect of 10% FBRA was observed until 16-17 weeks of age in the accumulated incidence and survival ratio compared with the unsupplemented conventional diet, although no significant difference was observed between 5% and 10% FBRA-supplemented diets. At the age of 12 weeks, which is just before the rats develop hepatitis, serum copper levels in rats fed either of the test diets were similar to those in rats fed the conventional diet. Furthermore, the copper concentration in liver tissue at 12 weeks of age was not changed by the test diet. These results suggest that FBRA has preventive effects on the development of hepatitis in LEC rats and may play an important role in protecting the liver against the free radicals induced by copper accumulation in the liver. |
| doi_str_mv | 10.3892/or.15.4.869 |
| format | Article |
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Both the 5% and 10% FBRA-supplemented diets indicated a tendency to prevent the development of hepatitis, and the significant effect of 10% FBRA was observed until 16-17 weeks of age in the accumulated incidence and survival ratio compared with the unsupplemented conventional diet, although no significant difference was observed between 5% and 10% FBRA-supplemented diets. At the age of 12 weeks, which is just before the rats develop hepatitis, serum copper levels in rats fed either of the test diets were similar to those in rats fed the conventional diet. Furthermore, the copper concentration in liver tissue at 12 weeks of age was not changed by the test diet. These results suggest that FBRA has preventive effects on the development of hepatitis in LEC rats and may play an important role in protecting the liver against the free radicals induced by copper accumulation in the liver.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.15.4.869</identifier><identifier>PMID: 16525673</identifier><language>eng</language><publisher>Athens: S.n.</publisher><subject>Acute Disease ; Animals ; Biological and medical sciences ; Body Weight - drug effects ; Diet ; Dose-Response Relationship, Drug ; Female ; Fermentation ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis - blood ; Hepatitis - mortality ; Hepatitis - prevention & control ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Oryza ; Oryza sativa ; Other diseases. Semiology ; Plant Preparations - administration & dosage ; Plant Preparations - pharmacology ; Rats ; Rats, Inbred LEC ; Survival Rate ; Time Factors ; Tumors</subject><ispartof>Oncology reports, 2006-04, Vol.15 (4), p.869-874</ispartof><rights>2006 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-58868cafbee4f3bf6490f83fcefe662e1edc9e1a3310e42f84cc52d82fa2f7533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17590448$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16525673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIBATA, Toshiyuki</creatorcontrib><creatorcontrib>NAGAYASU, Hiroki</creatorcontrib><creatorcontrib>KITAJO, Hiroyuki</creatorcontrib><creatorcontrib>ARISUE, Makoto</creatorcontrib><creatorcontrib>YAMASHITA, Tomomi</creatorcontrib><creatorcontrib>HATAKEYAMA, Daijiro</creatorcontrib><creatorcontrib>IWASAKI, Teruaki</creatorcontrib><creatorcontrib>KOBAYASHI, Hiroshi</creatorcontrib><title>Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>To investigate the effects of fermented brown rice (FBRA) on the development of hereditary hepatitis in Long-Evans Cinnamon (LEC) rats, we compared the incidence and grades of acute hepatitis among rats fed 5% and 10% FBRA in the conventional diet and the conventional diet alone. Both the 5% and 10% FBRA-supplemented diets indicated a tendency to prevent the development of hepatitis, and the significant effect of 10% FBRA was observed until 16-17 weeks of age in the accumulated incidence and survival ratio compared with the unsupplemented conventional diet, although no significant difference was observed between 5% and 10% FBRA-supplemented diets. At the age of 12 weeks, which is just before the rats develop hepatitis, serum copper levels in rats fed either of the test diets were similar to those in rats fed the conventional diet. Furthermore, the copper concentration in liver tissue at 12 weeks of age was not changed by the test diet. These results suggest that FBRA has preventive effects on the development of hepatitis in LEC rats and may play an important role in protecting the liver against the free radicals induced by copper accumulation in the liver.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Diet</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fermentation</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis - blood</subject><subject>Hepatitis - mortality</subject><subject>Hepatitis - prevention & control</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Oryza</subject><subject>Oryza sativa</subject><subject>Other diseases. Semiology</subject><subject>Plant Preparations - administration & dosage</subject><subject>Plant Preparations - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred LEC</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0T1v2zAQBmCiaNAkbqfuBZdmCeTwW9RYGPkCDGRJgG4ERR1rFhLpknQK99dXhg1kzHQ3PO8N9yL0lZIl1x27SXlJ5VIsteo-oAvadrRhgtOP804YbTiXP8_RZSm_CWEtUd0ndE6VZFK1_AL9e4yb0Iea8h6D9-BqwcljD3mCWGHAfU5_I87BAbZxOC59thGniOsG8ACvMKbtQR-C1u0q4A1sbQ01FBwiXqf4q7l9tbHgVYjRTnMy21o-ozNvxwJfTnOBXu5un1cPzfrp_nH1Y9040cnaSK2Vdtb3AMLz3ivREa-5d-BBKQYUBtcBtZxTAoJ5LZyTbNDMW-ZbyfkCXR3vbnP6s4NSzRSKg3G0EdKuGNW2nCgu3oWMKCZFS2Z4fYQup1IyeLPNYbJ5bygxh05MyoZKI8zcyay_nc7u-gmGN3sqYQbfT8AWZ0c_f9eF8uZa2REhNP8P1cmWYg</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>SHIBATA, Toshiyuki</creator><creator>NAGAYASU, Hiroki</creator><creator>KITAJO, Hiroyuki</creator><creator>ARISUE, Makoto</creator><creator>YAMASHITA, Tomomi</creator><creator>HATAKEYAMA, Daijiro</creator><creator>IWASAKI, Teruaki</creator><creator>KOBAYASHI, Hiroshi</creator><general>S.n.</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats</title><author>SHIBATA, Toshiyuki ; NAGAYASU, Hiroki ; KITAJO, Hiroyuki ; ARISUE, Makoto ; YAMASHITA, Tomomi ; HATAKEYAMA, Daijiro ; IWASAKI, Teruaki ; KOBAYASHI, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-58868cafbee4f3bf6490f83fcefe662e1edc9e1a3310e42f84cc52d82fa2f7533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Diet</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fermentation</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis - blood</topic><topic>Hepatitis - mortality</topic><topic>Hepatitis - prevention & control</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Oryza</topic><topic>Oryza sativa</topic><topic>Other diseases. Semiology</topic><topic>Plant Preparations - administration & dosage</topic><topic>Plant Preparations - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred LEC</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIBATA, Toshiyuki</creatorcontrib><creatorcontrib>NAGAYASU, Hiroki</creatorcontrib><creatorcontrib>KITAJO, Hiroyuki</creatorcontrib><creatorcontrib>ARISUE, Makoto</creatorcontrib><creatorcontrib>YAMASHITA, Tomomi</creatorcontrib><creatorcontrib>HATAKEYAMA, Daijiro</creatorcontrib><creatorcontrib>IWASAKI, Teruaki</creatorcontrib><creatorcontrib>KOBAYASHI, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIBATA, Toshiyuki</au><au>NAGAYASU, Hiroki</au><au>KITAJO, Hiroyuki</au><au>ARISUE, Makoto</au><au>YAMASHITA, Tomomi</au><au>HATAKEYAMA, Daijiro</au><au>IWASAKI, Teruaki</au><au>KOBAYASHI, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>15</volume><issue>4</issue><spage>869</spage><epage>874</epage><pages>869-874</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>To investigate the effects of fermented brown rice (FBRA) on the development of hereditary hepatitis in Long-Evans Cinnamon (LEC) rats, we compared the incidence and grades of acute hepatitis among rats fed 5% and 10% FBRA in the conventional diet and the conventional diet alone. Both the 5% and 10% FBRA-supplemented diets indicated a tendency to prevent the development of hepatitis, and the significant effect of 10% FBRA was observed until 16-17 weeks of age in the accumulated incidence and survival ratio compared with the unsupplemented conventional diet, although no significant difference was observed between 5% and 10% FBRA-supplemented diets. At the age of 12 weeks, which is just before the rats develop hepatitis, serum copper levels in rats fed either of the test diets were similar to those in rats fed the conventional diet. Furthermore, the copper concentration in liver tissue at 12 weeks of age was not changed by the test diet. These results suggest that FBRA has preventive effects on the development of hepatitis in LEC rats and may play an important role in protecting the liver against the free radicals induced by copper accumulation in the liver.</abstract><cop>Athens</cop><pub>S.n.</pub><pmid>16525673</pmid><doi>10.3892/or.15.4.869</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Animals Biological and medical sciences Body Weight - drug effects Diet Dose-Response Relationship, Drug Female Fermentation Gastroenterology. Liver. Pancreas. Abdomen Hepatitis - blood Hepatitis - mortality Hepatitis - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Oryza Oryza sativa Other diseases. Semiology Plant Preparations - administration & dosage Plant Preparations - pharmacology Rats Rats, Inbred LEC Survival Rate Time Factors Tumors |
| title | Inhibitory effects of fermented brown rice and rice bran on the development of acute hepatitis in Long-Evans Cinnamon rats |
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