Sp1: Regulation of gene expression by phosphorylation
As the prototype of a family of transcription factors, Sp1 has been extensively studied and widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was reported more than a decade ago. Since then, an increasing number of Sp1 phosphorylation events have been charact...
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| Veröffentlicht in: | Gene 2005-03, Vol.348, p.1-11 |
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| container_title | Gene |
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| creator | Chu, Shijian Ferro, Thomas J. |
| description | As the prototype of a family of transcription factors, Sp1 has been extensively studied and widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was reported more than a decade ago. Since then, an increasing number of Sp1 phosphorylation events have been characterized. Recent data demonstrate an important role for the phosphorylation state of Sp1 in the regulation of multiple genes. In this article, we review published literature in four specific areas relating to the phosphorylation of Sp1: (1) signal transduction pathways for Sp1 phosphorylation, (2) mechanisms of Sp1 dephosphorylation, (3) the functional implications of Sp1 phosphorylation, and (4) Sp1 phosphorylation in the lung. |
| doi_str_mv | 10.1016/j.gene.2005.01.013 |
| format | Article |
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In this article, we review published literature in four specific areas relating to the phosphorylation of Sp1: (1) signal transduction pathways for Sp1 phosphorylation, (2) mechanisms of Sp1 dephosphorylation, (3) the functional implications of Sp1 phosphorylation, and (4) Sp1 phosphorylation in the lung.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2005.01.013</identifier><identifier>PMID: 15777659</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Base Sequence ; Binding Sites - genetics ; DNA binding ; Gene Expression Regulation ; Humans ; Lung ; Phosphorylation ; Promoters ; Protein phosphatases ; Signal Transduction ; Signal transduction pathways ; Sp1 Transcription Factor - metabolism ; Transcription factors</subject><ispartof>Gene, 2005-03, Vol.348, p.1-11</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-baf162792f08cd0b64a8b615104e74123347dda773d80258facf053489ea51673</citedby><cites>FETCH-LOGICAL-c331t-baf162792f08cd0b64a8b615104e74123347dda773d80258facf053489ea51673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2005.01.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15777659$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chu, Shijian</creatorcontrib><creatorcontrib>Ferro, Thomas J.</creatorcontrib><title>Sp1: Regulation of gene expression by phosphorylation</title><title>Gene</title><addtitle>Gene</addtitle><description>As the prototype of a family of transcription factors, Sp1 has been extensively studied and widely reported for its role in gene regulation. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Base Sequence Binding Sites - genetics DNA binding Gene Expression Regulation Humans Lung Phosphorylation Promoters Protein phosphatases Signal Transduction Signal transduction pathways Sp1 Transcription Factor - metabolism Transcription factors |
| title | Sp1: Regulation of gene expression by phosphorylation |
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