CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells

The application of human embryonic stem (hES) cells in regenerative medicine will require rigorous quality control measures to ensure the safety of hES cell–derived grafts. During propagation in vitro , hES cells can acquire cytogenetic abnormalities 1 , 2 , 3 as well as submicroscopic genetic lesio...

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Veröffentlicht in:	Nature biotechnology 2006-03, Vol.24 (3), p.351-357
Hauptverfasser:	Herszfeld, Daniella, Wolvetang, Ernst, Langton-Bunker, Emma, Chung, Tung-Liang, Filipczyk, Adam A, Houssami, Souheir, Jamshidi, Pegah, Koh, Karen, Laslett, Andrew L, Michalska, Anna, Nguyen, Linh, Reubinoff, Benjamin E, Tellis, Irene, Auerbach, Jonathan M, Ording, Carol J, Looijenga, Leendert H J, Pera, Martin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Bioinformatics Biological and medical sciences Biomarkers - analysis Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Carcinoma, Embryonal - metabolism Carcinoma, Embryonal - pathology Cell Culture Techniques Cell Differentiation Cell Line, Transformed Cell Survival Cell Transformation, Neoplastic Cells, Cultured Fundamental and applied biological sciences. Psychology Genetic abnormalities Genetics Humans Immunohistochemistry Karyotyping Ki-1 Antigen - metabolism Lesions letter Life Sciences Medical research Oncology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Quality control Skin & tissue grafts Stem cells
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