Ionotropic and metabotropic glutamate receptor structure and pharmacology

L: -Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor families. The development of selective ligands, including competitive agonists and antagonists and positive and negative all...

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Veröffentlicht in:	Psychopharmacology 2005-04, Vol.179 (1), p.4-29
Hauptverfasser:	Kew, James N C, Kemp, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Binding, Competitive Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Humans Ligands Receptors, AMPA - chemistry Receptors, AMPA - drug effects Receptors, Kainic Acid - chemistry Receptors, Kainic Acid - drug effects Receptors, Metabotropic Glutamate - chemistry Receptors, Metabotropic Glutamate - drug effects Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - drug effects
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