Quantification of isosorbide 5-mononitrate in human plasma by liquid chromatography–tandem mass spectrometry using atmospheric pressure photoionization

Isosorbide 5-mononitrate (5-ISMN) is an organic nitrate widely used for its vasodilating properties in the treatment of angina pectoris. In the present study, an efficient, sensitive, robust method was developed for the determination and quantification of isosorbide 5-mononitrate, in human plasma, b...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2006-03, Vol.832 (2), p.302-306
Hauptverfasser:	Silva, Lara C., Oliveira, Lina S.O.B., Mendes, Gustavo D., Garcia, Gabriel, Pereira, Alberto dos Santos, De Nucci, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Atmospheric Pressure Biological and medical sciences Chromatography, Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology Human plasma Humans Isosorbide 5-mononitrate Isosorbide Dinitrate - analogs & derivatives Isosorbide Dinitrate - blood Mass Spectrometry - methods Medical sciences Pharmacology. Drug treatments Photochemistry Photospray Reference Standards Reproducibility of Results Sensitivity and Specificity Therapeutic Equivalency Vasodilator Agents - blood
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