Repetition of mGluR-dependent LTD causes slowly developing persistent reduction in synaptic strength accompanied by synapse elimination

Synaptic plasticity, the cellular basis of memory, operates in a bidirectional manner. LTP (long-term potentiation) is followed by structural changes that may lead to the formation of new synapses. However, little is known whether LTD (long-term depression) is followed by morphological changes. Here...

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Veröffentlicht in:	Brain research 2005-04, Vol.1042 (1), p.99-107
Hauptverfasser:	Shinoda, Yo, Kamikubo, Yuji, Egashira, Yoshihiro, Tominaga-Yoshino, Keiko, Ogura, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Electrophysiology Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - metabolism Hippocampus - ultrastructure Long-Term Synaptic Depression - physiology LTD Morphology Neurons - metabolism Neurons - ultrastructure Organ Culture Techniques Rats Receptors, Metabotropic Glutamate - metabolism Synapses - metabolism Synapses - ultrastructure Synaptic elimination Synaptic plasticity Time Factors Vertebrates: nervous system and sense organs
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