Antiangiogenic activity of 4- O-methylgallic acid from Canavalia gladiata, a dietary legume
Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4- O-methylgallic acid (4-OMGA) from the seed of Canavalia gladiata, a dietary legume, on the basis of the growth in...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2005-05, Vol.330 (4), p.1268-1274 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Jeon, Ki Suk Na, Hee-Jun Kim, Young-Myeong Kwon, Ho Jeong |
| description | Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-
O-methylgallic acid (4-OMGA) from the seed of
Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent. |
| doi_str_mv | 10.1016/j.bbrc.2005.03.109 |
| format | Article |
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O-methylgallic acid (4-OMGA) from the seed of
Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2005.03.109</identifier><identifier>PMID: 15823580</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>4- O-Methylgallic acid ; Angiogenesis Inhibitors - isolation & purification ; Angiogenesis Inhibitors - pharmacology ; Animals ; Antiangiogenic agent ; Aorta - cytology ; Aorta - drug effects ; Canavalia - chemistry ; Canavalia gladiata ; Cattle ; Cell Hypoxia ; Cells, Cultured ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Fibroblast Growth Factor 2 - pharmacology ; Gallic Acid - analogs & derivatives ; Gallic Acid - isolation & purification ; Gallic Acid - pharmacology ; Humans ; Plant Extracts - chemistry ; Reactive Oxygen Species - metabolism ; Seeds - chemistry ; Vascular Endothelial Growth Factor A - biosynthesis ; Vascular Endothelial Growth Factor A - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 2005-05, Vol.330 (4), p.1268-1274</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-a037d835b7aabef848035f55a64ebab2b31a8de07ace2c253dfe3560007947693</citedby><cites>FETCH-LOGICAL-c335t-a037d835b7aabef848035f55a64ebab2b31a8de07ace2c253dfe3560007947693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X05005899$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15823580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Ki Suk</creatorcontrib><creatorcontrib>Na, Hee-Jun</creatorcontrib><creatorcontrib>Kim, Young-Myeong</creatorcontrib><creatorcontrib>Kwon, Ho Jeong</creatorcontrib><title>Antiangiogenic activity of 4- O-methylgallic acid from Canavalia gladiata, a dietary legume</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Development of nontoxic and biologically safe antiangiogenic agent has been highlighted as a promising way to treat angiogenesis related diseases including cancer. Herein, we isolated 4-
O-methylgallic acid (4-OMGA) from the seed of
Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.</description><subject>4- O-Methylgallic acid</subject><subject>Angiogenesis Inhibitors - isolation & purification</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Antiangiogenic agent</subject><subject>Aorta - cytology</subject><subject>Aorta - drug effects</subject><subject>Canavalia - chemistry</subject><subject>Canavalia gladiata</subject><subject>Cattle</subject><subject>Cell Hypoxia</subject><subject>Cells, Cultured</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Fibroblast Growth Factor 2 - pharmacology</subject><subject>Gallic Acid - analogs & derivatives</subject><subject>Gallic Acid - isolation & purification</subject><subject>Gallic Acid - pharmacology</subject><subject>Humans</subject><subject>Plant Extracts - chemistry</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Seeds - chemistry</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>Vascular Endothelial Growth Factor A - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UE2LFDEQDeLijqt_wIPk5MkeK0mnP8DLMrgqLOxlBcFDqE6q2wzp7jXJDMy_t3tnwJuXKnj13qPeY-ydgK0AUX3ab7su2q0E0FtQC9a-YJtlQiEFlC_ZBgCqQrbi5zV7ndIeQIiyal-xa6EbqXQDG_brdsoep8HPA03ecrTZH30-8bnnZcEfipHy71MYMITnq3e8j_PIdzjhEYNHPgR0HjN-5Midp4zxxAMNh5HesKseQ6K3l33Dftx9edx9K-4fvn7f3d4XVimdCwRVu0bprkbsqG_KBpTutcaqpA472SmBjSOo0ZK0UivXk9LVEq5uy7pq1Q37cPZ9ivOfA6VsRp8shYATzYdkqrqWtRYrUZ6JNs4pRerNU_Tj8rARYNZKzd6slZq1UgNqwVbR-4v7oRvJ_ZNcOlwIn88EWjIePUWTrKfJkvORbDZu9v_z_ws_F4dx</recordid><startdate>20050520</startdate><enddate>20050520</enddate><creator>Jeon, Ki Suk</creator><creator>Na, Hee-Jun</creator><creator>Kim, Young-Myeong</creator><creator>Kwon, Ho Jeong</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050520</creationdate><title>Antiangiogenic activity of 4- O-methylgallic acid from Canavalia gladiata, a dietary legume</title><author>Jeon, Ki Suk ; 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O-methylgallic acid (4-OMGA) from the seed of
Canavalia gladiata, a dietary legume, on the basis of the growth inhibitory activity for bovine aortic endothelial cells (BAECs). The compound potently inhibits endothelial cell invasion and tube formation stimulated with basic fibroblast growth factor (bFGF) at low micromolar concentrations where it shows no cytotoxicity to the cells. In addition, 4-OMGA inhibits vascular endothelial cell growth factor (VEGF) production under hypoxic condition and the production of reactive oxygen species (ROS) in the endothelial cells stimulated with VEGF. These results demonstrate that 4-OMGA is a compound having potential for an antiangiogenic agent.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15823580</pmid><doi>10.1016/j.bbrc.2005.03.109</doi><tpages>7</tpages></addata></record> |
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| subjects | 4- O-Methylgallic acid Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals Antiangiogenic agent Aorta - cytology Aorta - drug effects Canavalia - chemistry Canavalia gladiata Cattle Cell Hypoxia Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Fibroblast Growth Factor 2 - pharmacology Gallic Acid - analogs & derivatives Gallic Acid - isolation & purification Gallic Acid - pharmacology Humans Plant Extracts - chemistry Reactive Oxygen Species - metabolism Seeds - chemistry Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - pharmacology |
| title | Antiangiogenic activity of 4- O-methylgallic acid from Canavalia gladiata, a dietary legume |
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