Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma
We have previously reported that the combination therapy of percutaneous ethanol injection and radiofrequency ablation (PEI-RFA) was more effective than RFA alone to induce wider coagulated necrosis for the treatment of hepatocellular carcinoma (HCC). In the present study, the effect of time-lag per...
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| Veröffentlicht in: | International journal of oncology 2006-04, Vol.28 (4), p.971-976 |
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| creator | KUROKOHCHI, Kazutaka MASAKI, Tsutomu KAKO, Takeshi OHMACHI, Naoko KIUCHI, Takaaki MAETA, Tsuyoshi YOSHIDA, Mitsuo MORI, Yoshihiro KOHI, Fumikazu KURIYAMA, Shigeki WATANABE, Seishiro NAKAI, Seiji DEGUCHI, Akihiro MORISHITA, Asahiro YONEYAMA, Hirohito OHGI, Tomohiro ONO, Masahiro YOSHITAKE, Akira |
| description | We have previously reported that the combination therapy of percutaneous ethanol injection and radiofrequency ablation (PEI-RFA) was more effective than RFA alone to induce wider coagulated necrosis for the treatment of hepatocellular carcinoma (HCC). In the present study, the effect of time-lag performance of RFA after PEI was evaluated under the same ablation condition as PEI-RFA by analyzing the volume of coagulated necrosis, the energy requirement for ablation and the amount of ethanol injected into HCC. The comparative study between time-lag PEI-RFA and no time-lag PEI-RFA showed that the total energy requirement and the energy requirement per unit volume for whole and marginal coagulated necrosis were significantly smaller in the time-lag group than in the no time-lag PEI-RFA group. In time-lag PEI-RFA, the volume of coagulated necrosis induced positively correlated with the amount of ethanol injected into HCC as previously observed in PEI-RFA treatment. These results suggest that time-lag PEI-RFA can induce comparable coagulated necrosis with a smaller energy requirement than no time-lag PEI-RFA, and that time-lag PEI-RFA is likely to be less invasive than no time-lag PEI-RFA for inducing comparable coagulated necrosis. Thus, time-lag performance of RFA after PEI may make RFA treatment more effective and less invasive for the treatment of patients with HCC. |
| doi_str_mv | 10.3892/ijo.28.4.971 |
| format | Article |
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In the present study, the effect of time-lag performance of RFA after PEI was evaluated under the same ablation condition as PEI-RFA by analyzing the volume of coagulated necrosis, the energy requirement for ablation and the amount of ethanol injected into HCC. The comparative study between time-lag PEI-RFA and no time-lag PEI-RFA showed that the total energy requirement and the energy requirement per unit volume for whole and marginal coagulated necrosis were significantly smaller in the time-lag group than in the no time-lag PEI-RFA group. In time-lag PEI-RFA, the volume of coagulated necrosis induced positively correlated with the amount of ethanol injected into HCC as previously observed in PEI-RFA treatment. These results suggest that time-lag PEI-RFA can induce comparable coagulated necrosis with a smaller energy requirement than no time-lag PEI-RFA, and that time-lag PEI-RFA is likely to be less invasive than no time-lag PEI-RFA for inducing comparable coagulated necrosis. Thus, time-lag performance of RFA after PEI may make RFA treatment more effective and less invasive for the treatment of patients with HCC.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.28.4.971</identifier><identifier>PMID: 16525648</identifier><language>eng</language><publisher>Athens: Editorial Academy of the International Journal of Oncology</publisher><subject>Aged ; Aged, 80 and over ; Anti-Infective Agents, Local - administration & dosage ; Anti-Infective Agents, Local - therapeutic use ; Biological and medical sciences ; Carcinoma, Hepatocellular - therapy ; Catheter Ablation - methods ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Ethanol - administration & dosage ; Ethanol - therapeutic use ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Injections, Intralesional ; Liver Neoplasms - therapy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Reproducibility of Results ; Treatment Outcome ; Tumors</subject><ispartof>International journal of oncology, 2006-04, Vol.28 (4), p.971-976</ispartof><rights>2006 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-83a68b145fbad00d632b001de7fcd06c796f2cb7b698ee8ee23cc86f371f52653</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17591754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16525648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUROKOHCHI, Kazutaka</creatorcontrib><creatorcontrib>MASAKI, Tsutomu</creatorcontrib><creatorcontrib>KAKO, Takeshi</creatorcontrib><creatorcontrib>OHMACHI, Naoko</creatorcontrib><creatorcontrib>KIUCHI, Takaaki</creatorcontrib><creatorcontrib>MAETA, Tsuyoshi</creatorcontrib><creatorcontrib>YOSHIDA, Mitsuo</creatorcontrib><creatorcontrib>MORI, Yoshihiro</creatorcontrib><creatorcontrib>KOHI, Fumikazu</creatorcontrib><creatorcontrib>KURIYAMA, Shigeki</creatorcontrib><creatorcontrib>WATANABE, Seishiro</creatorcontrib><creatorcontrib>NAKAI, Seiji</creatorcontrib><creatorcontrib>DEGUCHI, Akihiro</creatorcontrib><creatorcontrib>MORISHITA, Asahiro</creatorcontrib><creatorcontrib>YONEYAMA, Hirohito</creatorcontrib><creatorcontrib>OHGI, Tomohiro</creatorcontrib><creatorcontrib>ONO, Masahiro</creatorcontrib><creatorcontrib>YOSHITAKE, Akira</creatorcontrib><title>Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>We have previously reported that the combination therapy of percutaneous ethanol injection and radiofrequency ablation (PEI-RFA) was more effective than RFA alone to induce wider coagulated necrosis for the treatment of hepatocellular carcinoma (HCC). In the present study, the effect of time-lag performance of RFA after PEI was evaluated under the same ablation condition as PEI-RFA by analyzing the volume of coagulated necrosis, the energy requirement for ablation and the amount of ethanol injected into HCC. The comparative study between time-lag PEI-RFA and no time-lag PEI-RFA showed that the total energy requirement and the energy requirement per unit volume for whole and marginal coagulated necrosis were significantly smaller in the time-lag group than in the no time-lag PEI-RFA group. In time-lag PEI-RFA, the volume of coagulated necrosis induced positively correlated with the amount of ethanol injected into HCC as previously observed in PEI-RFA treatment. These results suggest that time-lag PEI-RFA can induce comparable coagulated necrosis with a smaller energy requirement than no time-lag PEI-RFA, and that time-lag PEI-RFA is likely to be less invasive than no time-lag PEI-RFA for inducing comparable coagulated necrosis. 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Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reproducibility of Results</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD2P1DAQhi0E4j6go0ZuoCKLP2I7LtEJOKSTaI7amjhj1qskXmynuJZfjpdd6aQZzRSPXs08hLzjbCcHKz7HQ9qJYdfvrOEvyDU3lneiF_Jl2xm3ne6lvSI3pRwYE0ox_ppcca2E0v1wTf4-xgW7GX7TI-aQ8gKrR5oCzTDFFDL-2XD1TxTGGWpMK4VQMZ9gv1VYMW2FYt3DmmYa1wP6_1ALonWPtGaEuuBaT4l7PEJNHud5myFTD9nHNS3whrwKMBd8e5m35Ne3r493993Dz-8_7r48dF4qU7tBgh5G3qswwsTYpKUYGeMTmuAnpr2xOgg_mlHbAbGVkN4POkjDgxJayVvy8Zx7zKl9VapbYjmdc37DaWOEYcY28NMZ9DmVkjG4Y44L5CfHmTs5d825E4PrXXPe8PeX3G1ccHqGL5Ib8OECQPEwh9wcx_LMGWVb9_IfUySN_Q</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>KUROKOHCHI, Kazutaka</creator><creator>MASAKI, Tsutomu</creator><creator>KAKO, Takeshi</creator><creator>OHMACHI, Naoko</creator><creator>KIUCHI, Takaaki</creator><creator>MAETA, Tsuyoshi</creator><creator>YOSHIDA, Mitsuo</creator><creator>MORI, Yoshihiro</creator><creator>KOHI, Fumikazu</creator><creator>KURIYAMA, Shigeki</creator><creator>WATANABE, Seishiro</creator><creator>NAKAI, Seiji</creator><creator>DEGUCHI, Akihiro</creator><creator>MORISHITA, Asahiro</creator><creator>YONEYAMA, Hirohito</creator><creator>OHGI, Tomohiro</creator><creator>ONO, Masahiro</creator><creator>YOSHITAKE, Akira</creator><general>Editorial Academy of the International Journal of Oncology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma</title><author>KUROKOHCHI, Kazutaka ; MASAKI, Tsutomu ; KAKO, Takeshi ; OHMACHI, Naoko ; KIUCHI, Takaaki ; MAETA, Tsuyoshi ; YOSHIDA, Mitsuo ; MORI, Yoshihiro ; KOHI, Fumikazu ; KURIYAMA, Shigeki ; WATANABE, Seishiro ; NAKAI, Seiji ; DEGUCHI, Akihiro ; MORISHITA, Asahiro ; YONEYAMA, Hirohito ; OHGI, Tomohiro ; ONO, Masahiro ; YOSHITAKE, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-83a68b145fbad00d632b001de7fcd06c796f2cb7b698ee8ee23cc86f371f52653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Anti-Infective Agents, Local - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Catheter Ablation - methods</topic><topic>Combined Modality Therapy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - therapeutic use</topic><topic>Female</topic><topic>Gastroenterology. 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In the present study, the effect of time-lag performance of RFA after PEI was evaluated under the same ablation condition as PEI-RFA by analyzing the volume of coagulated necrosis, the energy requirement for ablation and the amount of ethanol injected into HCC. The comparative study between time-lag PEI-RFA and no time-lag PEI-RFA showed that the total energy requirement and the energy requirement per unit volume for whole and marginal coagulated necrosis were significantly smaller in the time-lag group than in the no time-lag PEI-RFA group. In time-lag PEI-RFA, the volume of coagulated necrosis induced positively correlated with the amount of ethanol injected into HCC as previously observed in PEI-RFA treatment. These results suggest that time-lag PEI-RFA can induce comparable coagulated necrosis with a smaller energy requirement than no time-lag PEI-RFA, and that time-lag PEI-RFA is likely to be less invasive than no time-lag PEI-RFA for inducing comparable coagulated necrosis. Thus, time-lag performance of RFA after PEI may make RFA treatment more effective and less invasive for the treatment of patients with HCC.</abstract><cop>Athens</cop><pub>Editorial Academy of the International Journal of Oncology</pub><pmid>16525648</pmid><doi>10.3892/ijo.28.4.971</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - therapeutic use Biological and medical sciences Carcinoma, Hepatocellular - therapy Catheter Ablation - methods Combined Modality Therapy Dose-Response Relationship, Drug Ethanol - administration & dosage Ethanol - therapeutic use Female Gastroenterology. Liver. Pancreas. Abdomen Humans Injections, Intralesional Liver Neoplasms - therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Reproducibility of Results Treatment Outcome Tumors |
| title | Time-lag performance of radiofrequency ablation after percutaneous ethanol injection for the treatment of hepatocellular carcinoma |
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