Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats
To determine whether administration of Crandell-Rees feline kidney (CRFK) cell lysates or vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP vaccines) that likely contain CRFK cell proteins induces antibodies against CRFK cell or feline renal cell (FRC) lysates in c...
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Veröffentlicht in: | American journal of veterinary research 2005-03, Vol.66 (3), p.506-511 |
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creator | Lappin, M.R Jensen, W.A Jensen, T.D Basaraba, R.J Brown, C.A Radecki, S.V Hawley, J.R |
description | To determine whether administration of Crandell-Rees feline kidney (CRFK) cell lysates or vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP vaccines) that likely contain CRFK cell proteins induces antibodies against CRFK cell or feline renal cell (FRC) lysates in cats.
14 eight-week-old cats.
Before and after the study, renal biopsy specimens were obtained from each cat for histologic evaluation. Each of 4 FVRCP vaccines was administered to 2 cats at weeks 0, 3, 6, and 50. Between weeks 0 and 50, another 3 pairs of cats received 11 CRFK cell lysate inoculations SC (10, 50, or 50 microg mixed with alum). Clinicopathologic evaluations and ELISAs to detect serum antibodies against CRFK cell or FRC lysates were performed at intervals.
Cats had no antibodies against CRFK cell or FRC lysates initially. All cats administered CRFK cell lysate had detectable antibodies against CRFK cell or FRC lysates on multiple occasions. Of 6 cats vaccinated parenterally, 5 had detectable antibodies against CRFK cell lysate at least once, but all 6 had detectable antibodies against FRC lysate on multiple occasions. Cats administered an intranasal-intraocular vaccine did not develop detectable antibodies against either lysate. Important clinicopathologic or histologic abnormalities were not detected during the study.
Parenteral administration of vaccines containing viruses likely grown on CRFK cells induced antibodies against CRFK cell and FRC lysates in cats. Hypersensitization with CRFK cell proteins did not result in renal disease in cats during the 56-week study. |
doi_str_mv | 10.2460/ajvr.2005.66.506 |
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14 eight-week-old cats.
Before and after the study, renal biopsy specimens were obtained from each cat for histologic evaluation. Each of 4 FVRCP vaccines was administered to 2 cats at weeks 0, 3, 6, and 50. Between weeks 0 and 50, another 3 pairs of cats received 11 CRFK cell lysate inoculations SC (10, 50, or 50 microg mixed with alum). Clinicopathologic evaluations and ELISAs to detect serum antibodies against CRFK cell or FRC lysates were performed at intervals.
Cats had no antibodies against CRFK cell or FRC lysates initially. All cats administered CRFK cell lysate had detectable antibodies against CRFK cell or FRC lysates on multiple occasions. Of 6 cats vaccinated parenterally, 5 had detectable antibodies against CRFK cell lysate at least once, but all 6 had detectable antibodies against FRC lysate on multiple occasions. Cats administered an intranasal-intraocular vaccine did not develop detectable antibodies against either lysate. Important clinicopathologic or histologic abnormalities were not detected during the study.
Parenteral administration of vaccines containing viruses likely grown on CRFK cells induced antibodies against CRFK cell and FRC lysates in cats. Hypersensitization with CRFK cell proteins did not result in renal disease in cats during the 56-week study.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.2005.66.506</identifier><identifier>PMID: 15822597</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; antibodies ; Antibody Formation - immunology ; biopsy ; Biopsy - veterinary ; blood serum ; Calicivirus, Feline - immunology ; cat diseases ; cats ; Cats - immunology ; Cell Extracts - immunology ; Cell Line ; clinical examination ; detection ; dosage ; drug injection ; enzyme-linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - veterinary ; eyes ; Felid herpesvirus 1 ; Feline calicivirus ; feline panleukopenia ; Feline panleukopenia virus ; Feline Panleukopenia Virus - immunology ; Herpesviridae - immunology ; histology ; hypersensitivity ; immune response ; intranasal administration ; intraocular administration ; Kidney - cytology ; Kidney - pathology ; kidney cells ; vaccines ; viral diseases of animals and humans ; Viral Vaccines - administration & dosage</subject><ispartof>American journal of veterinary research, 2005-03, Vol.66 (3), p.506-511</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-7cf74331b4c02e6f75ea410c7b0f47a8a88f9f188257592486f92c7a84ebaa063</citedby><cites>FETCH-LOGICAL-c410t-7cf74331b4c02e6f75ea410c7b0f47a8a88f9f188257592486f92c7a84ebaa063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15822597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lappin, M.R</creatorcontrib><creatorcontrib>Jensen, W.A</creatorcontrib><creatorcontrib>Jensen, T.D</creatorcontrib><creatorcontrib>Basaraba, R.J</creatorcontrib><creatorcontrib>Brown, C.A</creatorcontrib><creatorcontrib>Radecki, S.V</creatorcontrib><creatorcontrib>Hawley, J.R</creatorcontrib><title>Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To determine whether administration of Crandell-Rees feline kidney (CRFK) cell lysates or vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP vaccines) that likely contain CRFK cell proteins induces antibodies against CRFK cell or feline renal cell (FRC) lysates in cats.
14 eight-week-old cats.
Before and after the study, renal biopsy specimens were obtained from each cat for histologic evaluation. Each of 4 FVRCP vaccines was administered to 2 cats at weeks 0, 3, 6, and 50. Between weeks 0 and 50, another 3 pairs of cats received 11 CRFK cell lysate inoculations SC (10, 50, or 50 microg mixed with alum). Clinicopathologic evaluations and ELISAs to detect serum antibodies against CRFK cell or FRC lysates were performed at intervals.
Cats had no antibodies against CRFK cell or FRC lysates initially. All cats administered CRFK cell lysate had detectable antibodies against CRFK cell or FRC lysates on multiple occasions. Of 6 cats vaccinated parenterally, 5 had detectable antibodies against CRFK cell lysate at least once, but all 6 had detectable antibodies against FRC lysate on multiple occasions. Cats administered an intranasal-intraocular vaccine did not develop detectable antibodies against either lysate. Important clinicopathologic or histologic abnormalities were not detected during the study.
Parenteral administration of vaccines containing viruses likely grown on CRFK cells induced antibodies against CRFK cell and FRC lysates in cats. Hypersensitization with CRFK cell proteins did not result in renal disease in cats during the 56-week study.</description><subject>Animals</subject><subject>antibodies</subject><subject>Antibody Formation - immunology</subject><subject>biopsy</subject><subject>Biopsy - veterinary</subject><subject>blood serum</subject><subject>Calicivirus, Feline - immunology</subject><subject>cat diseases</subject><subject>cats</subject><subject>Cats - immunology</subject><subject>Cell Extracts - immunology</subject><subject>Cell Line</subject><subject>clinical examination</subject><subject>detection</subject><subject>dosage</subject><subject>drug injection</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>eyes</subject><subject>Felid herpesvirus 1</subject><subject>Feline calicivirus</subject><subject>feline panleukopenia</subject><subject>Feline panleukopenia virus</subject><subject>Feline Panleukopenia Virus - immunology</subject><subject>Herpesviridae - immunology</subject><subject>histology</subject><subject>hypersensitivity</subject><subject>immune response</subject><subject>intranasal administration</subject><subject>intraocular administration</subject><subject>Kidney - cytology</subject><subject>Kidney - pathology</subject><subject>kidney cells</subject><subject>vaccines</subject><subject>viral diseases of animals and humans</subject><subject>Viral Vaccines - administration & dosage</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1DAUhS0EokNhzwqyYtUMtuO_LNEISqVKSEDX1o1jz7jNOMF2Rpr35gFwmCmVWNm-37nn2j4IvSV4TZnAH-H-ENcUY74WYs2xeIZWpGVNzYUiz9EKY0zrVjB-gV6ldI8xoYrwl-iCcEUpb-UK_b4JB5uy30L2Y6hGV-WdrXzoZ_NYgJB9N_bepgq24EPK1SZC6O0w1N9tqTo7-GCrB98He6xMqVfDMUFeGkL_iKMNMPxHXbaxmqCgsikU-r0PPuX47zYHMKZ0P40-ux38oo87H8aiNjvrs09XlYHBG1_gXA7L8AnCYOeHcbLBQ3lXUeT0Gr1wMCT75rxeorsvn39uvta3365vNp9ua8MIzrU0TrKmIR0zmFrhJLdQgJEddkyCAqVc64hSlEveUqaEa6kpgNkOAIvmEn04-U5x_DWXb9Z7n5YfgGDHOWkhJRWS4SLEJ6GJY0rROj1Fv4d41ATrJWm9JK2XpLUQmv_1fnf2nru97Z8aztEWwfuTwMGoYRt90nc_KCYNxq3igrDmDwnBtgs</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Lappin, M.R</creator><creator>Jensen, W.A</creator><creator>Jensen, T.D</creator><creator>Basaraba, R.J</creator><creator>Brown, C.A</creator><creator>Radecki, S.V</creator><creator>Hawley, J.R</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats</title><author>Lappin, M.R ; Jensen, W.A ; Jensen, T.D ; Basaraba, R.J ; Brown, C.A ; Radecki, S.V ; Hawley, J.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-7cf74331b4c02e6f75ea410c7b0f47a8a88f9f188257592486f92c7a84ebaa063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>antibodies</topic><topic>Antibody Formation - immunology</topic><topic>biopsy</topic><topic>Biopsy - veterinary</topic><topic>blood serum</topic><topic>Calicivirus, Feline - immunology</topic><topic>cat diseases</topic><topic>cats</topic><topic>Cats - immunology</topic><topic>Cell Extracts - immunology</topic><topic>Cell Line</topic><topic>clinical examination</topic><topic>detection</topic><topic>dosage</topic><topic>drug injection</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>eyes</topic><topic>Felid herpesvirus 1</topic><topic>Feline calicivirus</topic><topic>feline panleukopenia</topic><topic>Feline panleukopenia virus</topic><topic>Feline Panleukopenia Virus - immunology</topic><topic>Herpesviridae - immunology</topic><topic>histology</topic><topic>hypersensitivity</topic><topic>immune response</topic><topic>intranasal administration</topic><topic>intraocular administration</topic><topic>Kidney - cytology</topic><topic>Kidney - pathology</topic><topic>kidney cells</topic><topic>vaccines</topic><topic>viral diseases of animals and humans</topic><topic>Viral Vaccines - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lappin, M.R</creatorcontrib><creatorcontrib>Jensen, W.A</creatorcontrib><creatorcontrib>Jensen, T.D</creatorcontrib><creatorcontrib>Basaraba, R.J</creatorcontrib><creatorcontrib>Brown, C.A</creatorcontrib><creatorcontrib>Radecki, S.V</creatorcontrib><creatorcontrib>Hawley, J.R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lappin, M.R</au><au>Jensen, W.A</au><au>Jensen, T.D</au><au>Basaraba, R.J</au><au>Brown, C.A</au><au>Radecki, S.V</au><au>Hawley, J.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>66</volume><issue>3</issue><spage>506</spage><epage>511</epage><pages>506-511</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To determine whether administration of Crandell-Rees feline kidney (CRFK) cell lysates or vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP vaccines) that likely contain CRFK cell proteins induces antibodies against CRFK cell or feline renal cell (FRC) lysates in cats.
14 eight-week-old cats.
Before and after the study, renal biopsy specimens were obtained from each cat for histologic evaluation. Each of 4 FVRCP vaccines was administered to 2 cats at weeks 0, 3, 6, and 50. Between weeks 0 and 50, another 3 pairs of cats received 11 CRFK cell lysate inoculations SC (10, 50, or 50 microg mixed with alum). Clinicopathologic evaluations and ELISAs to detect serum antibodies against CRFK cell or FRC lysates were performed at intervals.
Cats had no antibodies against CRFK cell or FRC lysates initially. All cats administered CRFK cell lysate had detectable antibodies against CRFK cell or FRC lysates on multiple occasions. Of 6 cats vaccinated parenterally, 5 had detectable antibodies against CRFK cell lysate at least once, but all 6 had detectable antibodies against FRC lysate on multiple occasions. Cats administered an intranasal-intraocular vaccine did not develop detectable antibodies against either lysate. Important clinicopathologic or histologic abnormalities were not detected during the study.
Parenteral administration of vaccines containing viruses likely grown on CRFK cells induced antibodies against CRFK cell and FRC lysates in cats. Hypersensitization with CRFK cell proteins did not result in renal disease in cats during the 56-week study.</abstract><cop>United States</cop><pmid>15822597</pmid><doi>10.2460/ajvr.2005.66.506</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals antibodies Antibody Formation - immunology biopsy Biopsy - veterinary blood serum Calicivirus, Feline - immunology cat diseases cats Cats - immunology Cell Extracts - immunology Cell Line clinical examination detection dosage drug injection enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - veterinary eyes Felid herpesvirus 1 Feline calicivirus feline panleukopenia Feline panleukopenia virus Feline Panleukopenia Virus - immunology Herpesviridae - immunology histology hypersensitivity immune response intranasal administration intraocular administration Kidney - cytology Kidney - pathology kidney cells vaccines viral diseases of animals and humans Viral Vaccines - administration & dosage |
title | Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats |
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