Interleukin-15 rescues tolerant CD8 + T cells for use in adoptive immunotherapy of established tumors

CD8+ T cells can mediate eradication of established tumors, and strategies to amplify tumor-reactive T-cell numbers by immunization or ex vivo expansion followed by adoptive transfer are currently being explored in individuals with cancer. Generating effective CD8+ T cell-mediated responses to tumor...

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Veröffentlicht in:	Nature medicine 2006-03, Vol.12 (3), p.335-341
Hauptverfasser:	Greenberg, Philip D, Teague, Ryan M, Sather, Blythe D, Sacks, Jilian A, Huang, Maria Z, Dossett, Michelle L, Morimoto, Junko, Tan, Xiaoxio, Sutton, Susan E, Cooke, Michael P, Öhlén, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Proliferation Fas Ligand Protein Humans Immune Tolerance - immunology Immunization Immunologic Memory - immunology Immunology Immunotherapy Immunotherapy, Adoptive Infectious Diseases Interleukin-15 - pharmacology letter Leukemia Medical research Membrane Glycoproteins - metabolism Metabolic Diseases Mice Mice, Inbred C57BL Mice, Transgenic Molecular Medicine Neoplasms - therapy Neurosciences Receptors, Interleukin-15 Receptors, Interleukin-2 - metabolism T cell receptors Tumor Necrosis Factors - metabolism Tumors
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