Administration of haloperidol with biperiden reduces mRNAs related to the ubiquitin-proteasome system in mice

In order to find molecules affected by administration of an antipsychotic drug with an antimuscarinic drug, which is a common prescription used to prevent extrapyramidal adverse effects caused by the antipsychotic drugs, gene expression profiling in the frontal cortex was studied in mice. After 14 d...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 2005-06, Vol.56 (4), p.175-184
Hauptverfasser:	Iwata, Shin-ichi, Morioka, Hirofumi, Iwabuchi, Mika, Shinohara, Kazuya, Maeda, Maki, Shimizu, Takao, Miyata, Atsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Animals ATAC-PCR Biperiden - administration & dosage dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - pharmacology Down-Regulation - drug effects Drug Combinations Frontal Lobe - drug effects Frontal Lobe - metabolism gene expression profiling Gene Expression Profiling - methods Haloperidol - administration & dosage Male Mice Muscarinic Antagonists - administration & dosage Muscarinic Antagonists - pharmacology Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism the frontal cortex Ubiquitin - genetics Ubiquitin - metabolism
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