Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology

Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. Both estrogens and androgens are synthesized in male hippocampus. These brain st...

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Veröffentlicht in:	Neuroscience 2006-01, Vol.138 (3), p.757-764
Hauptverfasser:	Mukai, H., Takata, N., Ishii, H.-t., Tanabe, N., Hojo, Y., Furukawa, A., Kimoto, T., Kawato, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - biosynthesis Androgens - physiology Animals Biological and medical sciences Brain - metabolism Cytochrome P-450 Enzyme System - metabolism endocrine disrupter estradiol Estrogens - biosynthesis Estrogens - physiology Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - metabolism Humans Neuronal Plasticity - physiology Neurons - physiology neurosteroid P450 Rats Synapses - physiology Vertebrates: nervous system and sense organs
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