Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology
Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. Both estrogens and androgens are synthesized in male hippocampus. These brain st...
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Veröffentlicht in: | Neuroscience 2006-01, Vol.138 (3), p.757-764 |
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description | Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. Both estrogens and androgens are synthesized in male hippocampus. These brain steroids are synthesized by cytochrome P450s (P450scc, P45017α and P450arom), hydroxysteroid dehydrogenases and reductases from endogenous cholesterol. The expression levels of enzymes are as low as 1/300–1/1000 of those in endocrine organs. Synthesis is dependent on the acute Ca
2+ influx upon neuron–neuron communication via NMDA receptors. Estradiol is particularly important because estradiol rapidly modulates neuronal synaptic transmission such as long-term potentiation via synaptic estrogen receptors. Xenoestrogens may also act via estrogen-driven signaling pathways. |
doi_str_mv | 10.1016/j.neuroscience.2005.09.010 |
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2+ influx upon neuron–neuron communication via NMDA receptors. Estradiol is particularly important because estradiol rapidly modulates neuronal synaptic transmission such as long-term potentiation via synaptic estrogen receptors. Xenoestrogens may also act via estrogen-driven signaling pathways.</description><subject>Androgens - biosynthesis</subject><subject>Androgens - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>endocrine disrupter</subject><subject>estradiol</subject><subject>Estrogens - biosynthesis</subject><subject>Estrogens - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons - physiology</subject><subject>neurosteroid</subject><subject>P450</subject><subject>Rats</subject><subject>Synapses - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQQC1ERZe2fwFFSHBLOo5jJ-kNlY8iVeIAnK1ZZ9z1KomDnQD77_F2I5UbWLJGY72Zsf0Ye82h4MDV9b4YaQk-GkejoaIEkAW0BXB4xja8qUVey6p6zjYgQOWVLMtz9jLGPaQlK_GCnXMlOAguN-z3nZsmb3CYsM_iYZx3FF3MvM0ozsE_0BgzHLvjXrNfO2d2GQbKJgxoghspG3y39Dj78FiZ2uA0O5NNPcYU3Xy4yb4-Hvoj73v_cLhkZxb7SFdrvGDfP374dnuX33_59Pn23X1uJMg5V7bllkosWyXJguiMqZoaFYEsQZqtACsbWyI3aKmRhGKLW0JTJq4TthYX7O2p7xT8jyU9Sg8uGup7HMkvUau6LmXdNv8EeQ1KCqkSeHMCTXIQA1k9BTdgOGgO-ihI7_XfgvRRkIZWJ0Gp-NU6ZdkO1D2VrkYS8GYFMBrsbcDRuPjE1appeMUT9_7EUfq8n46CXsd1LpCZdefd_9znD8mquls</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Mukai, H.</creator><creator>Takata, N.</creator><creator>Ishii, H.-t.</creator><creator>Tanabe, N.</creator><creator>Hojo, Y.</creator><creator>Furukawa, A.</creator><creator>Kimoto, T.</creator><creator>Kawato, S.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology</title><author>Mukai, H. ; Takata, N. ; Ishii, H.-t. ; Tanabe, N. ; Hojo, Y. ; Furukawa, A. ; Kimoto, T. ; Kawato, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-6f91fe2a2965ef03dcc487a6e05205cb30f58f2a1cafe85ea3babeac2cc4d3f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Androgens - biosynthesis</topic><topic>Androgens - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>endocrine disrupter</topic><topic>estradiol</topic><topic>Estrogens - biosynthesis</topic><topic>Estrogens - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurons - physiology</topic><topic>neurosteroid</topic><topic>P450</topic><topic>Rats</topic><topic>Synapses - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukai, H.</creatorcontrib><creatorcontrib>Takata, N.</creatorcontrib><creatorcontrib>Ishii, H.-t.</creatorcontrib><creatorcontrib>Tanabe, N.</creatorcontrib><creatorcontrib>Hojo, Y.</creatorcontrib><creatorcontrib>Furukawa, A.</creatorcontrib><creatorcontrib>Kimoto, T.</creatorcontrib><creatorcontrib>Kawato, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukai, H.</au><au>Takata, N.</au><au>Ishii, H.-t.</au><au>Tanabe, N.</au><au>Hojo, Y.</au><au>Furukawa, A.</au><au>Kimoto, T.</au><au>Kawato, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>138</volume><issue>3</issue><spage>757</spage><epage>764</epage><pages>757-764</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Hippocampal pyramidal neurons and granule neurons of adult male rats are equipped with a complete machinery for the synthesis of pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone and 17β-estradiol. 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subjects | Androgens - biosynthesis Androgens - physiology Animals Biological and medical sciences Brain - metabolism Cytochrome P-450 Enzyme System - metabolism endocrine disrupter estradiol Estrogens - biosynthesis Estrogens - physiology Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - metabolism Humans Neuronal Plasticity - physiology Neurons - physiology neurosteroid P450 Rats Synapses - physiology Vertebrates: nervous system and sense organs |
title | Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: Synaptocrinology |
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