In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla
OBJECTIVES:We sought to demonstrate the feasibility of using single-shot spin-echo echo-planar imaging for imaging liver tumor necrosis in the in vivo VX2 rabbit model at 1.5 T. MATERIALS AND METHODS:VX2 liver tumors were grown in 4 rabbits. Diffusion-weighted images (DWIs) were acquired during brea...
Gespeichert in:
| Veröffentlicht in: | Investigative radiology 2006-04, Vol.41 (4), p.410-414 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 414 |
|---|---|
| container_issue | 4 |
| container_start_page | 410 |
| container_title | Investigative radiology |
| container_volume | 41 |
| creator | Deng, Jie Rhee, Thomas K Sato, Kent T Salem, Riad Haines, Kenneth Paunesku, Tatjana Mulcahy, Mary F Miller, Frank H Omary, Reed A Larson, Andrew C |
| description | OBJECTIVES:We sought to demonstrate the feasibility of using single-shot spin-echo echo-planar imaging for imaging liver tumor necrosis in the in vivo VX2 rabbit model at 1.5 T.
MATERIALS AND METHODS:VX2 liver tumors were grown in 4 rabbits. Diffusion-weighted images (DWIs) were acquired during breath-hold using twice refocused SE-EPI (b = 0, 700, 1400 seconds/mm). Anatomic images for tumor size measurements were acquired using T2W TSE. Rabbits were euthanized for subsequent necropsy. Viable and necrotic tumor tissue ADC measurements were performed with reference to hematoxylin and eosin pathology.
RESULTS:A total of 8 tumors were grown with diameters ranging from 1.2 to 5.3 cm. Viable and necrotic tumor compartments were clearly differentiated. Apparent diffusion coefficient in necrotic tumor cores, 1.26 ± 0.11 × 10 mm/s, were significantly greater than those in surrounding viable tumor tissues, 0.74 ± 0.06 × 10 mm/s (mean ± SD, P < 0.05).
CONCLUSIONS:In vivo DWI of liver tumor necrosis in the VX2 rabbit model is feasible using a 1.5 T clinical magnetic resonance imaging scanner. DWI may permit longitudinal assessment of liver tumor therapies in both preclinical and clinical studies. |
| doi_str_mv | 10.1097/01.rli.0000201232.14903.da |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67725635</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67725635</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4287-92f8161601c507b9c726c349cc1be8a7efeb1bb7b1f313d3d28e0047fb83f0013</originalsourceid><addsrcrecordid>eNpFkE1v1DAQhi0EokvhLyCLA7eEGduJE26ofK20gISWws2yk_GuIR_FTlrx70m6K9WXkT3PvCM_jL1CyBFq_QYwj13IYTkCUEiRo6pB5q19xDZYyDIDgfCYbdZ-Vtd1ecGepfR75TXIp-wCy0JIEGrDzHbg1-F25O-D93MK45D9pHA4TtTybW8PYTjw0fNduKXI93M_Rv6VmjimkHgY-HQkfv1L8O_WuTDxL2NLHbcTx7zge0qdfc6eeNslenGul-zHxw_7q8_Z7tun7dW7XdYoUemsFr7CEkvApgDt6kaLspGqbhp0VFlNnhw6px16ibKVragIQGnvKukBUF6y16fcmzj-nSlNpg-poa6zA41zMqXWoihlsYBvT-D6iRTJm5sYehv_GQSz6jWAZtFrHvSae72mtcvwy_OW2fXUPoyefS6AOgF3YzdRTH-6-Y6iOZLtpuN9pFJCZQKgBLXcsvVJy_8_0IUG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67725635</pqid></control><display><type>article</type><title>In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Deng, Jie ; Rhee, Thomas K ; Sato, Kent T ; Salem, Riad ; Haines, Kenneth ; Paunesku, Tatjana ; Mulcahy, Mary F ; Miller, Frank H ; Omary, Reed A ; Larson, Andrew C</creator><creatorcontrib>Deng, Jie ; Rhee, Thomas K ; Sato, Kent T ; Salem, Riad ; Haines, Kenneth ; Paunesku, Tatjana ; Mulcahy, Mary F ; Miller, Frank H ; Omary, Reed A ; Larson, Andrew C</creatorcontrib><description>OBJECTIVES:We sought to demonstrate the feasibility of using single-shot spin-echo echo-planar imaging for imaging liver tumor necrosis in the in vivo VX2 rabbit model at 1.5 T.
MATERIALS AND METHODS:VX2 liver tumors were grown in 4 rabbits. Diffusion-weighted images (DWIs) were acquired during breath-hold using twice refocused SE-EPI (b = 0, 700, 1400 seconds/mm). Anatomic images for tumor size measurements were acquired using T2W TSE. Rabbits were euthanized for subsequent necropsy. Viable and necrotic tumor tissue ADC measurements were performed with reference to hematoxylin and eosin pathology.
RESULTS:A total of 8 tumors were grown with diameters ranging from 1.2 to 5.3 cm. Viable and necrotic tumor compartments were clearly differentiated. Apparent diffusion coefficient in necrotic tumor cores, 1.26 ± 0.11 × 10 mm/s, were significantly greater than those in surrounding viable tumor tissues, 0.74 ± 0.06 × 10 mm/s (mean ± SD, P < 0.05).
CONCLUSIONS:In vivo DWI of liver tumor necrosis in the VX2 rabbit model is feasible using a 1.5 T clinical magnetic resonance imaging scanner. DWI may permit longitudinal assessment of liver tumor therapies in both preclinical and clinical studies.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/01.rli.0000201232.14903.da</identifier><identifier>PMID: 16523024</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Cell Line, Tumor ; Feasibility Studies ; Image Processing, Computer-Assisted ; Liver Neoplasms - pathology ; Magnetic Resonance Imaging - methods ; Necrosis ; Rabbits</subject><ispartof>Investigative radiology, 2006-04, Vol.41 (4), p.410-414</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4287-92f8161601c507b9c726c349cc1be8a7efeb1bb7b1f313d3d28e0047fb83f0013</citedby><cites>FETCH-LOGICAL-c4287-92f8161601c507b9c726c349cc1be8a7efeb1bb7b1f313d3d28e0047fb83f0013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16523024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Jie</creatorcontrib><creatorcontrib>Rhee, Thomas K</creatorcontrib><creatorcontrib>Sato, Kent T</creatorcontrib><creatorcontrib>Salem, Riad</creatorcontrib><creatorcontrib>Haines, Kenneth</creatorcontrib><creatorcontrib>Paunesku, Tatjana</creatorcontrib><creatorcontrib>Mulcahy, Mary F</creatorcontrib><creatorcontrib>Miller, Frank H</creatorcontrib><creatorcontrib>Omary, Reed A</creatorcontrib><creatorcontrib>Larson, Andrew C</creatorcontrib><title>In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>OBJECTIVES:We sought to demonstrate the feasibility of using single-shot spin-echo echo-planar imaging for imaging liver tumor necrosis in the in vivo VX2 rabbit model at 1.5 T.
MATERIALS AND METHODS:VX2 liver tumors were grown in 4 rabbits. Diffusion-weighted images (DWIs) were acquired during breath-hold using twice refocused SE-EPI (b = 0, 700, 1400 seconds/mm). Anatomic images for tumor size measurements were acquired using T2W TSE. Rabbits were euthanized for subsequent necropsy. Viable and necrotic tumor tissue ADC measurements were performed with reference to hematoxylin and eosin pathology.
RESULTS:A total of 8 tumors were grown with diameters ranging from 1.2 to 5.3 cm. Viable and necrotic tumor compartments were clearly differentiated. Apparent diffusion coefficient in necrotic tumor cores, 1.26 ± 0.11 × 10 mm/s, were significantly greater than those in surrounding viable tumor tissues, 0.74 ± 0.06 × 10 mm/s (mean ± SD, P < 0.05).
CONCLUSIONS:In vivo DWI of liver tumor necrosis in the VX2 rabbit model is feasible using a 1.5 T clinical magnetic resonance imaging scanner. DWI may permit longitudinal assessment of liver tumor therapies in both preclinical and clinical studies.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Feasibility Studies</subject><subject>Image Processing, Computer-Assisted</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Necrosis</subject><subject>Rabbits</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAQhi0EokvhLyCLA7eEGduJE26ofK20gISWws2yk_GuIR_FTlrx70m6K9WXkT3PvCM_jL1CyBFq_QYwj13IYTkCUEiRo6pB5q19xDZYyDIDgfCYbdZ-Vtd1ecGepfR75TXIp-wCy0JIEGrDzHbg1-F25O-D93MK45D9pHA4TtTybW8PYTjw0fNduKXI93M_Rv6VmjimkHgY-HQkfv1L8O_WuTDxL2NLHbcTx7zge0qdfc6eeNslenGul-zHxw_7q8_Z7tun7dW7XdYoUemsFr7CEkvApgDt6kaLspGqbhp0VFlNnhw6px16ibKVragIQGnvKukBUF6y16fcmzj-nSlNpg-poa6zA41zMqXWoihlsYBvT-D6iRTJm5sYehv_GQSz6jWAZtFrHvSae72mtcvwy_OW2fXUPoyefS6AOgF3YzdRTH-6-Y6iOZLtpuN9pFJCZQKgBLXcsvVJy_8_0IUG</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Deng, Jie</creator><creator>Rhee, Thomas K</creator><creator>Sato, Kent T</creator><creator>Salem, Riad</creator><creator>Haines, Kenneth</creator><creator>Paunesku, Tatjana</creator><creator>Mulcahy, Mary F</creator><creator>Miller, Frank H</creator><creator>Omary, Reed A</creator><creator>Larson, Andrew C</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla</title><author>Deng, Jie ; Rhee, Thomas K ; Sato, Kent T ; Salem, Riad ; Haines, Kenneth ; Paunesku, Tatjana ; Mulcahy, Mary F ; Miller, Frank H ; Omary, Reed A ; Larson, Andrew C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4287-92f8161601c507b9c726c349cc1be8a7efeb1bb7b1f313d3d28e0047fb83f0013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Feasibility Studies</topic><topic>Image Processing, Computer-Assisted</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Necrosis</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Jie</creatorcontrib><creatorcontrib>Rhee, Thomas K</creatorcontrib><creatorcontrib>Sato, Kent T</creatorcontrib><creatorcontrib>Salem, Riad</creatorcontrib><creatorcontrib>Haines, Kenneth</creatorcontrib><creatorcontrib>Paunesku, Tatjana</creatorcontrib><creatorcontrib>Mulcahy, Mary F</creatorcontrib><creatorcontrib>Miller, Frank H</creatorcontrib><creatorcontrib>Omary, Reed A</creatorcontrib><creatorcontrib>Larson, Andrew C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Jie</au><au>Rhee, Thomas K</au><au>Sato, Kent T</au><au>Salem, Riad</au><au>Haines, Kenneth</au><au>Paunesku, Tatjana</au><au>Mulcahy, Mary F</au><au>Miller, Frank H</au><au>Omary, Reed A</au><au>Larson, Andrew C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>2006-04</date><risdate>2006</risdate><volume>41</volume><issue>4</issue><spage>410</spage><epage>414</epage><pages>410-414</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>OBJECTIVES:We sought to demonstrate the feasibility of using single-shot spin-echo echo-planar imaging for imaging liver tumor necrosis in the in vivo VX2 rabbit model at 1.5 T.
MATERIALS AND METHODS:VX2 liver tumors were grown in 4 rabbits. Diffusion-weighted images (DWIs) were acquired during breath-hold using twice refocused SE-EPI (b = 0, 700, 1400 seconds/mm). Anatomic images for tumor size measurements were acquired using T2W TSE. Rabbits were euthanized for subsequent necropsy. Viable and necrotic tumor tissue ADC measurements were performed with reference to hematoxylin and eosin pathology.
RESULTS:A total of 8 tumors were grown with diameters ranging from 1.2 to 5.3 cm. Viable and necrotic tumor compartments were clearly differentiated. Apparent diffusion coefficient in necrotic tumor cores, 1.26 ± 0.11 × 10 mm/s, were significantly greater than those in surrounding viable tumor tissues, 0.74 ± 0.06 × 10 mm/s (mean ± SD, P < 0.05).
CONCLUSIONS:In vivo DWI of liver tumor necrosis in the VX2 rabbit model is feasible using a 1.5 T clinical magnetic resonance imaging scanner. DWI may permit longitudinal assessment of liver tumor therapies in both preclinical and clinical studies.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16523024</pmid><doi>10.1097/01.rli.0000201232.14903.da</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-9996 |
| ispartof | Investigative radiology, 2006-04, Vol.41 (4), p.410-414 |
| issn | 0020-9996 1536-0210 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67725635 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Cell Line, Tumor Feasibility Studies Image Processing, Computer-Assisted Liver Neoplasms - pathology Magnetic Resonance Imaging - methods Necrosis Rabbits |
| title | In Vivo Diffusion-Weighted Imaging of Liver Tumor Necrosis in the VX2 Rabbit Model at 1.5 Tesla |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T20%3A27%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vivo%20Diffusion-Weighted%20Imaging%20of%20Liver%20Tumor%20Necrosis%20in%20the%20VX2%20Rabbit%20Model%20at%201.5%20Tesla&rft.jtitle=Investigative%20radiology&rft.au=Deng,%20Jie&rft.date=2006-04&rft.volume=41&rft.issue=4&rft.spage=410&rft.epage=414&rft.pages=410-414&rft.issn=0020-9996&rft.eissn=1536-0210&rft_id=info:doi/10.1097/01.rli.0000201232.14903.da&rft_dat=%3Cproquest_cross%3E67725635%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67725635&rft_id=info:pmid/16523024&rfr_iscdi=true |