Recombinant human erythropoietin produced in milk of transgenic pigs

We have developed a line of transgenic swine harboring recombinant human erythropoietin through microinjection into fertilized one cell pig zygotes. Milk from generations F 1 and F 2 transgenic females was analyzed, and hEPO was detected in milk from all lactating females at concentrations of approx...

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Veröffentlicht in:	Journal of biotechnology 2006-04, Vol.122 (3), p.362-371
Hauptverfasser:	Park, Jin-Ki, Lee, Yun-Keun, Lee, Poongyeon, Chung, Hak-Jae, Kim, Sungwoo, Lee, Hyun-Gi, Seo, Myung-Kyu, Han, Joo-Hee, Park, Chun-Gyu, Kim, Hun-Taek, Kim, Yong-Kook, Min, Kwan-Sik, Kim, Jin-Hoi, Lee, Hoon-Taek, Chang, Won-Kyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological and medical sciences Biotechnology Bone Marrow Cells - cytology Cell Line Cell Proliferation Erythropoietin Erythropoietin - genetics Erythropoietin - metabolism Expression Female Fundamental and applied biological sciences. Psychology gene transfer genetic transformation Humans lactation Male Mammary gland Mammary Glands, Animal - metabolism Microinjection Milk - metabolism protein secretion Recombinant Proteins sow milk Sus scrofa - genetics swine transgenes Transgenic animals zygote
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