A Central Strategy for Converting Natural Products into Fluorescent Probes
A centralized method for studying natural product chemical biology begins by designating a single fluorescent dye as a core reporter and develops through the facile conversion to a diverse panel of fluorescently labeled natural products. Comparative analyses are developed by using LED fluorescence m...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2006-03, Vol.7 (3), p.409-416 |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Alexander, Matthew D. Burkart, Michael D. Leonard, Michael S. Portonovo, Padma Liang, Bo Ding, Xiaobin Joullié, Madeleine M. Gulledge, Brian M. Aggen, James B. Chamberlin, A. Richard Sandler, Joel Fenical, William Cui, Jian Gharpure, Santosh J. Polosukhin, Alexei Zhang, Hai-Ren Evans, P. Andrew Richardson, Adam D. Harper, Mary Kay Ireland, Chris M. Vong, Binh G. Brady, Thomas P. Theodorakis, Emmanuel A. La Clair, James J. |
| description | A centralized method for studying natural product chemical biology begins by designating a single fluorescent dye as a core reporter and develops through the facile conversion to a diverse panel of fluorescently labeled natural products. Comparative analyses are developed by using LED fluorescence microscopy. Application of this method is established by profiling the cellular uptake and localization of selected members of the anthracycline, acetogenin, depsipeptide, nonribosomal peptide, polyether, and polyketide families of natural products. |
| doi_str_mv | 10.1002/cbic.200500466 |
| format | Article |
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Richard ; Sandler, Joel ; Fenical, William ; Cui, Jian ; Gharpure, Santosh J. ; Polosukhin, Alexei ; Zhang, Hai-Ren ; Evans, P. Andrew ; Richardson, Adam D. ; Harper, Mary Kay ; Ireland, Chris M. ; Vong, Binh G. ; Brady, Thomas P. ; Theodorakis, Emmanuel A. ; La Clair, James J.</creator><creatorcontrib>Alexander, Matthew D. ; Burkart, Michael D. ; Leonard, Michael S. ; Portonovo, Padma ; Liang, Bo ; Ding, Xiaobin ; Joullié, Madeleine M. ; Gulledge, Brian M. ; Aggen, James B. ; Chamberlin, A. Richard ; Sandler, Joel ; Fenical, William ; Cui, Jian ; Gharpure, Santosh J. ; Polosukhin, Alexei ; Zhang, Hai-Ren ; Evans, P. 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| identifier | ISSN: 1439-4227 |
| ispartof | Chembiochem : a European journal of chemical biology, 2006-03, Vol.7 (3), p.409-416 |
| issn | 1439-4227 1439-7633 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Biological Products - chemistry Biological Products - metabolism cell biology fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism HeLa Cells Humans microscopy Microscopy, Fluorescence natural products organelle labels total synthesis |
| title | A Central Strategy for Converting Natural Products into Fluorescent Probes |
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