Exaggerated coronary vasoreactivity to endothelin-1 in aged rats : Role of protein kinase C

The interaction between advanced age and increased susceptibility to ischemic insult is well documented. Age-related increases in coronary vascular resistance, in part due to impaired dilator responses, have been reported. Our aim was to determine the role of endothelin-1 (ET-1) on enhanced constric...

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Veröffentlicht in:	Cardiovascular research 2005-05, Vol.66 (2), p.384-392
Hauptverfasser:	KORZICK, Donna H, MULLER-DELP, Judy M, DOUGHERTY, Patrick, HEAPS, Christine L, BOWLES, Douglas K, KRICK, Kevin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biological and medical sciences Calcium Channels, P-Type - metabolism Cardiology. Vascular system Coronary heart disease Coronary Vessels - drug effects Coronary Vessels - metabolism Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists Endothelin-1 - pharmacology Heart In Vitro Techniques Indoles - pharmacology Male Maleimides - pharmacology Medical sciences Oligopeptides - pharmacology Peptides, Cyclic - pharmacology Piperidines - pharmacology Potassium Chloride - pharmacology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Rats Rats, Inbred F344 Vasoconstrictor Agents - pharmacology
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