Cell death and sexual differentiation of the nervous system
Sex differences in nuclear volume or neuron number often are attributed to the hormonal control of cell death. In the spinal nucleus of the bulbocavernosus, the central portion of the medial preoptic nucleus, and the principal nucleus of the bed nucleus of the stria terminalis testicular hormones de...
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| Veröffentlicht in: | Neuroscience 2006-01, Vol.138 (3), p.929-938 |
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| creator | Forger, N.G. |
| description | Sex differences in nuclear volume or neuron number often are attributed to the hormonal control of cell death. In the spinal nucleus of the bulbocavernosus, the central portion of the medial preoptic nucleus, and the principal nucleus of the bed nucleus of the stria terminalis testicular hormones decrease cell death during perinatal life, resulting in a male advantage in neuron number in adulthood. Conversely, males have more dying cells during development and fewer neurons in adulthood than do females in the anteroventral periventricular nucleus of the hypothalamus. This review discusses several limitations and unresolved issues in the literature on sexually dimorphic cell death, and identifies molecular mechanisms by which gonadal steroids may control cell survival. In particular, evidence is presented for the hormonal regulation of neurotrophic factors and involvement of Bcl-2 family proteins in the determination of sex differences in neuron number. |
| doi_str_mv | 10.1016/j.neuroscience.2005.07.006 |
| format | Article |
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In the spinal nucleus of the bulbocavernosus, the central portion of the medial preoptic nucleus, and the principal nucleus of the bed nucleus of the stria terminalis testicular hormones decrease cell death during perinatal life, resulting in a male advantage in neuron number in adulthood. Conversely, males have more dying cells during development and fewer neurons in adulthood than do females in the anteroventral periventricular nucleus of the hypothalamus. This review discusses several limitations and unresolved issues in the literature on sexually dimorphic cell death, and identifies molecular mechanisms by which gonadal steroids may control cell survival. 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Psychology</subject><subject>Genes, bcl-2</subject><subject>Male</subject><subject>Models, Neurological</subject><subject>Nervous System - growth & development</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>neurotrophic factor</subject><subject>Receptors, Androgen - physiology</subject><subject>Receptors, Estrogen - physiology</subject><subject>Sex Differentiation</subject><subject>sexual differentiation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LAzEQhoMotlb_giyC3nadNF9bPUn9hIIXPYfs7oSmtLs12S3235vShXrTXBKGZzLvPIRcUcgoUHm7yGrsfBNKh3WJ2RhAZKAyAHlEhjRXLFWC82MyBAYy5WI8HpCzEBYQj-DslAyoZBQYlUNyP8XlMqnQtPPE1FUS8LszseCsRY9160zrmjppbNLOManRb5ouJGEbWlydkxNrlgEv-ntEPp-fPqav6ez95W36MEtLAaJNc8uKPIeJAM5FIeKzUjlCTkXcBpkUAgqJoiom0irBCmqBcRYXNROUtuBsRG72_65989VhaPXKhTLmNjXGNFoqNWYTBn-CVIHkO3hE7vZgGTUGj1avvVsZv9UU9M6xXujfjvXOsQalo-PYfNlP6YoVVofWXmoErnvAhNIsrTd16cKBUzLPqdzFfdxzGOVtHHrdj6ucx7LVVeP-k-cHiTefTg</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Forger, N.G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Cell death and sexual differentiation of the nervous system</title><author>Forger, N.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-8f3b880950445b5880d78e0815101e36550b6e5db96f753b1f0343016a9e6fb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bax</topic><topic>Bcl-2</topic><topic>Biological and medical sciences</topic><topic>cell death</topic><topic>Cell Death - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, bcl-2</topic><topic>Male</topic><topic>Models, Neurological</topic><topic>Nervous System - growth & development</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>neurotrophic factor</topic><topic>Receptors, Androgen - physiology</topic><topic>Receptors, Estrogen - physiology</topic><topic>Sex Differentiation</topic><topic>sexual differentiation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forger, N.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forger, N.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell death and sexual differentiation of the nervous system</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>138</volume><issue>3</issue><spage>929</spage><epage>938</epage><pages>929-938</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Sex differences in nuclear volume or neuron number often are attributed to the hormonal control of cell death. 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| ispartof | Neuroscience, 2006-01, Vol.138 (3), p.929-938 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bax Bcl-2 Biological and medical sciences cell death Cell Death - physiology Female Fundamental and applied biological sciences. Psychology Genes, bcl-2 Male Models, Neurological Nervous System - growth & development Neurons - cytology Neurons - physiology neurotrophic factor Receptors, Androgen - physiology Receptors, Estrogen - physiology Sex Differentiation sexual differentiation Vertebrates: nervous system and sense organs |
| title | Cell death and sexual differentiation of the nervous system |
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