Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice

Mutations in the presenilins (PS) account for the majority of familial Alzheimer disease (FAD) cases. To test the hypothesis that oxidative stress can underlie the deleterious effects of presenilin mutations, we analyzed lipid peroxidation products (4-hydroxynonenal (HNE) and malondialdehyde) and an...

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Veröffentlicht in:	Free radical biology & medicine 2006-03, Vol.40 (5), p.850-862
Hauptverfasser:	Schuessel, Katrin, Frey, Claudia, Jourdan, Claudia, Keil, Uta, Weber, Claudia C., Müller-Spahn, Franz, Müller, Walter E., Eckert, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - metabolism Aldehydes - analysis Aldehydes - metabolism Alzheimer disease Amyloid β Animals Antioxidant enzyme Apoptosis Brain Brain - metabolism Brain Chemistry CD4-Positive T-Lymphocytes - chemistry CD4-Positive T-Lymphocytes - metabolism Cytosol - chemistry Free radical Humans Hydroxynonenal Lipid Peroxidation Lymphocyte Malondialdehyde - analysis Membrane Proteins - genetics Mice Mice, Transgenic Mitochondria Mitochondria - chemistry Mitochondria - metabolism Mutation Oxidative Stress Presenilin Presenilin-1 Reactive oxygen species Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism Spleen - cytology Transgenic Transgenic mouse
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