The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”
The aim of this study was to investigate the relationship of serum FSH and LH levels at the commencement of stimulation to ovarian follicular development in women undergoing pituitary down-regulation and controlled ovarian hyperstimulation with gonadotropins in IVF or intracytoplasmic sperm injectio...
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| Veröffentlicht in: | Fertility and sterility 2005-04, Vol.83 (4), p.883-888 |
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| creator | Ho, Jason Yen-Ping Guu, Hwa-Fen Yi, Yu-Chiao Chen, Ming-Jer Ho, Esther Shih-Chu |
| description | The aim of this study was to investigate the relationship of serum FSH and LH levels at the commencement of stimulation to ovarian follicular development in women undergoing pituitary down-regulation and controlled ovarian hyperstimulation with gonadotropins in IVF or intracytoplasmic sperm injection (ICSI) cycles.
Retrospective analysis.
An IVF program in a tertiary medical center.
A total of 245 women proven to be pituitary down-regulated by their serum E
2 levels.
Patients treated with a GnRH agonist and FSH and hMG underwent assisted reproductive technique (ART).
Mature oocyte yield, pregnancy rate (PR), and live birth rate.
The serum FSH levels and the FSH-to-LH ratio at the commencement of gonadotropin stimulation were inversely correlated to the number of mature oocytes (
r = −0.193 and
r = −0.224, respectively). When assessed with receiver-operating characteristic (ROC) analysis, there was statistically significant ability for the FSH/LH ratio to differentiate between the “poor response” cycles (with mature oocyte yield ≤4) and the normal response cycles. Using the cutoff value derived from ROC analysis, cycles with the FSH-to-LH ratio ≥3 produced less mature oocytes (8.25 vs. 11.74), lower peak E
2 levels (1,975.3 pg/mL vs. 3,324.8 pg/mL), and higher percentage of poor ovarian response cycles (32.5% vs. 14.3%).
The serum FSH-to-LH ratio at the start of gonadotropin stimulation after pituitary down-regulation provided a practical method for early prediction of mature oocyte yield. |
| doi_str_mv | 10.1016/j.fertnstert.2004.10.040 |
| format | Article |
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Retrospective analysis.
An IVF program in a tertiary medical center.
A total of 245 women proven to be pituitary down-regulated by their serum E
2 levels.
Patients treated with a GnRH agonist and FSH and hMG underwent assisted reproductive technique (ART).
Mature oocyte yield, pregnancy rate (PR), and live birth rate.
The serum FSH levels and the FSH-to-LH ratio at the commencement of gonadotropin stimulation were inversely correlated to the number of mature oocytes (
r = −0.193 and
r = −0.224, respectively). When assessed with receiver-operating characteristic (ROC) analysis, there was statistically significant ability for the FSH/LH ratio to differentiate between the “poor response” cycles (with mature oocyte yield ≤4) and the normal response cycles. Using the cutoff value derived from ROC analysis, cycles with the FSH-to-LH ratio ≥3 produced less mature oocytes (8.25 vs. 11.74), lower peak E
2 levels (1,975.3 pg/mL vs. 3,324.8 pg/mL), and higher percentage of poor ovarian response cycles (32.5% vs. 14.3%).
The serum FSH-to-LH ratio at the start of gonadotropin stimulation after pituitary down-regulation provided a practical method for early prediction of mature oocyte yield.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2004.10.040</identifier><identifier>PMID: 15820795</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers ; Down-regulation ; Down-Regulation - drug effects ; Female ; Fertility Agents, Female - administration & dosage ; Follicle Stimulating Hormone - blood ; FSH ; FSH-to-LH ratio ; Gonadotropin-Releasing Hormone - agonists ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Female - blood ; Infertility, Female - diagnosis ; Infertility, Female - drug therapy ; Luteinizing Hormone - blood ; Medical sciences ; Menotropins - administration & dosage ; oocyte yield ; Oocytes - cytology ; Ovary - cytology ; Ovary - drug effects ; Ovulation Induction ; Pituitary Gland - drug effects ; Pituitary Gland - metabolism ; poor ovarian response ; Predictive Value of Tests ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies</subject><ispartof>Fertility and sterility, 2005-04, Vol.83 (4), p.883-888</ispartof><rights>2005 American Society for Reproductive Medicine</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-3bb3915a5ebb4d3b331de41e463d85ad386cc912a9013431f56ba30f8981fd6b3</citedby><cites>FETCH-LOGICAL-c452t-3bb3915a5ebb4d3b331de41e463d85ad386cc912a9013431f56ba30f8981fd6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028204032121$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16705969$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15820795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, Jason Yen-Ping</creatorcontrib><creatorcontrib>Guu, Hwa-Fen</creatorcontrib><creatorcontrib>Yi, Yu-Chiao</creatorcontrib><creatorcontrib>Chen, Ming-Jer</creatorcontrib><creatorcontrib>Ho, Esther Shih-Chu</creatorcontrib><title>The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The aim of this study was to investigate the relationship of serum FSH and LH levels at the commencement of stimulation to ovarian follicular development in women undergoing pituitary down-regulation and controlled ovarian hyperstimulation with gonadotropins in IVF or intracytoplasmic sperm injection (ICSI) cycles.
Retrospective analysis.
An IVF program in a tertiary medical center.
A total of 245 women proven to be pituitary down-regulated by their serum E
2 levels.
Patients treated with a GnRH agonist and FSH and hMG underwent assisted reproductive technique (ART).
Mature oocyte yield, pregnancy rate (PR), and live birth rate.
The serum FSH levels and the FSH-to-LH ratio at the commencement of gonadotropin stimulation were inversely correlated to the number of mature oocytes (
r = −0.193 and
r = −0.224, respectively). When assessed with receiver-operating characteristic (ROC) analysis, there was statistically significant ability for the FSH/LH ratio to differentiate between the “poor response” cycles (with mature oocyte yield ≤4) and the normal response cycles. Using the cutoff value derived from ROC analysis, cycles with the FSH-to-LH ratio ≥3 produced less mature oocytes (8.25 vs. 11.74), lower peak E
2 levels (1,975.3 pg/mL vs. 3,324.8 pg/mL), and higher percentage of poor ovarian response cycles (32.5% vs. 14.3%).
The serum FSH-to-LH ratio at the start of gonadotropin stimulation after pituitary down-regulation provided a practical method for early prediction of mature oocyte yield.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Down-regulation</subject><subject>Down-Regulation - drug effects</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>FSH</subject><subject>FSH-to-LH ratio</subject><subject>Gonadotropin-Releasing Hormone - agonists</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - diagnosis</subject><subject>Infertility, Female - drug therapy</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Menotropins - administration & dosage</subject><subject>oocyte yield</subject><subject>Oocytes - cytology</subject><subject>Ovary - cytology</subject><subject>Ovary - drug effects</subject><subject>Ovulation Induction</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>poor ovarian response</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Retrospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O0zAQxiMEYsvCK6C5wC1dO47d5Agr_qy0EpflHDn2pHXl2MF2tiqnfRB4uT3yFLhqody42NLM7_tmNF9RACVLSqi42i4HDMnFlN9lRUidy0tSkyfFgnIuSi44e1osCKG8JFVTXRQvYtwSQgRdVc-LC8qbiqxavih-3W0QIoZ5hMFba5TFMiYzzlYm49aw8WH0DsvkSzsnNM58_6cMIVMeZIJ0sEkyJPAD_DXwDnYmbWDtndQ-BT8ZF0EOeW-YTJpNVuxB-50rA67_SEwE4-4xRLR7UD4EzA3URysJo0xzQPBe7RPC3qDVIJ0GJR1MAbVRCR4ffli_g4Bx8k5nq8eHny-LZ4O0EV-d_svi68cPd9efy9svn26u392WquZVKlnfs5ZyybHva816xqjGmmItmG641KwRSrW0ki2hrGZ04KKXjAxN29BBi55dFm-PvlPw32aMqRtNVGitdOjn2InVqmI15RlsjqAKPsaAQzcFM-aLdJR0h5y7bXfOuTvkfOjknLP09WnG3I-oz8JTsBl4cwJkVNIOQTpl4pkTK8Jb0Wbu_ZHDfJF7g6GLyqBT-YwBVeq0N__f5jf16ta6</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Ho, Jason Yen-Ping</creator><creator>Guu, Hwa-Fen</creator><creator>Yi, Yu-Chiao</creator><creator>Chen, Ming-Jer</creator><creator>Ho, Esther Shih-Chu</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”</title><author>Ho, Jason Yen-Ping ; Guu, Hwa-Fen ; Yi, Yu-Chiao ; Chen, Ming-Jer ; Ho, Esther Shih-Chu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-3bb3915a5ebb4d3b331de41e463d85ad386cc912a9013431f56ba30f8981fd6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Down-regulation</topic><topic>Down-Regulation - drug effects</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>FSH</topic><topic>FSH-to-LH ratio</topic><topic>Gonadotropin-Releasing Hormone - agonists</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - diagnosis</topic><topic>Infertility, Female - drug therapy</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Menotropins - administration & dosage</topic><topic>oocyte yield</topic><topic>Oocytes - cytology</topic><topic>Ovary - cytology</topic><topic>Ovary - drug effects</topic><topic>Ovulation Induction</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>poor ovarian response</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Jason Yen-Ping</creatorcontrib><creatorcontrib>Guu, Hwa-Fen</creatorcontrib><creatorcontrib>Yi, Yu-Chiao</creatorcontrib><creatorcontrib>Chen, Ming-Jer</creatorcontrib><creatorcontrib>Ho, Esther Shih-Chu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Jason Yen-Ping</au><au>Guu, Hwa-Fen</au><au>Yi, Yu-Chiao</au><au>Chen, Ming-Jer</au><au>Ho, Esther Shih-Chu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders”</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>83</volume><issue>4</issue><spage>883</spage><epage>888</epage><pages>883-888</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>The aim of this study was to investigate the relationship of serum FSH and LH levels at the commencement of stimulation to ovarian follicular development in women undergoing pituitary down-regulation and controlled ovarian hyperstimulation with gonadotropins in IVF or intracytoplasmic sperm injection (ICSI) cycles.
Retrospective analysis.
An IVF program in a tertiary medical center.
A total of 245 women proven to be pituitary down-regulated by their serum E
2 levels.
Patients treated with a GnRH agonist and FSH and hMG underwent assisted reproductive technique (ART).
Mature oocyte yield, pregnancy rate (PR), and live birth rate.
The serum FSH levels and the FSH-to-LH ratio at the commencement of gonadotropin stimulation were inversely correlated to the number of mature oocytes (
r = −0.193 and
r = −0.224, respectively). When assessed with receiver-operating characteristic (ROC) analysis, there was statistically significant ability for the FSH/LH ratio to differentiate between the “poor response” cycles (with mature oocyte yield ≤4) and the normal response cycles. Using the cutoff value derived from ROC analysis, cycles with the FSH-to-LH ratio ≥3 produced less mature oocytes (8.25 vs. 11.74), lower peak E
2 levels (1,975.3 pg/mL vs. 3,324.8 pg/mL), and higher percentage of poor ovarian response cycles (32.5% vs. 14.3%).
The serum FSH-to-LH ratio at the start of gonadotropin stimulation after pituitary down-regulation provided a practical method for early prediction of mature oocyte yield.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15820795</pmid><doi>10.1016/j.fertnstert.2004.10.040</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2005-04, Vol.83 (4), p.883-888 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_67723415 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Biomarkers Down-regulation Down-Regulation - drug effects Female Fertility Agents, Female - administration & dosage Follicle Stimulating Hormone - blood FSH FSH-to-LH ratio Gonadotropin-Releasing Hormone - agonists Gynecology. Andrology. Obstetrics Humans Infertility, Female - blood Infertility, Female - diagnosis Infertility, Female - drug therapy Luteinizing Hormone - blood Medical sciences Menotropins - administration & dosage oocyte yield Oocytes - cytology Ovary - cytology Ovary - drug effects Ovulation Induction Pituitary Gland - drug effects Pituitary Gland - metabolism poor ovarian response Predictive Value of Tests Pregnancy Pregnancy Outcome Retrospective Studies |
| title | The serum follicle-stimulating hormone-to-luteinizing hormone ratio at the start of stimulation with gonadotropins after pituitary down-regulation is inversely correlated with a mature oocyte yield and can predict “low responders” |
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