Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection

Equipe Accueil 3737 Pathologie des Cellules Lymphoides, Universite Claude Bernard, France. BACKGROUND AND OBJECTIVES: To clarify the relationship between splenic (SMZL) and nodal marginal zone (NMZL) lymphomas, we analyzed immunoglobulin variable heavy chain (VH) gene usage and mutation patterns in...

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Veröffentlicht in:	Haematologica (Roma) 2005-04, Vol.90 (4), p.470-478
Hauptverfasser:	Traverse-Glehen, A, Davi, F, Ben Simon, E, Callet-Bauchu, E, Felman, P, Baseggio, L, Gazzo, S, Thieblemont, C, Charlot, C, Coiffier, B, Berger, F, Salles, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Clonal Anergy - genetics Female Genes, Immunoglobulin - physiology Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic Diseases - blood Lymphatic Diseases - genetics Lymphoma, B-Cell - blood Lymphoma, B-Cell - genetics Male Medical sciences Middle Aged Splenic Neoplasms - blood Splenic Neoplasms - genetics
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