Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells

FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular mechanisms controlling immune tolerance. Although the biological relevance of this transcription factor is well documented, the pathways responsible for its induction are still unclear. The current study revea...

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Veröffentlicht in:	Journal of Immunology 2006-03, Vol.176 (6), p.3593-3602
Hauptverfasser:	Mantel, Pierre-Yves, Ouaked, Nadia, Ruckert, Beate, Karagiannidis, Christian, Welz, Roland, Blaser, Kurt, Schmidt-Weber, Carsten B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cells, Cultured Chromatin - genetics Cyclosporine - pharmacology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation - drug effects Humans Organ Specificity Promoter Regions, Genetic - genetics Receptors, Antigen, T-Cell - metabolism Receptors, Interleukin-2 - metabolism T-Lymphocytes - drug effects T-Lymphocytes - metabolism Transcription, Genetic - genetics
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