Immunization with Murine Breast Cancer Cells Treated with Antisense Oligodeoxynucleotides to Type I Insulin-Like Growth Factor Receptor Induced an Antitumoral Effect Mediated by a CD8+ Response Involving Fas/Fas Ligand Cytotoxic Pathway

We have demonstrated that in vivo administration of phosphorothioate antisense oligodeoxynucleotides (AS[S]ODNs) to type I insulin-like growth factor receptor (IGF-IR) mRNA resulted in inhibition of C4HD breast cancer growth in BALB/c mice. The present study focused on whether in vivo administration...

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Veröffentlicht in:	The Journal of immunology (1950) 2006-03, Vol.176 (6), p.3426-3437
Hauptverfasser:	Schillaci, Roxana, Salatino, Mariana, Cassataro, Juliana, Proietti, Cecilia J, Giambartolomei, Guillermo H, Rivas, Martin A, Carnevale, Romina P, Charreau, Eduardo H, Elizalde, Patricia V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B7-2 Antigen - metabolism Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Vaccines - immunology Cell Proliferation Cells, Cultured Fas Ligand Protein fas Receptor - metabolism Female HSP70 Heat-Shock Proteins - metabolism Immunization Interferon-gamma - biosynthesis Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Transplantation Oligodeoxyribonucleotides, Antisense - genetics Phenotype Receptor, IGF Type 1 - deficiency Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor Necrosis Factors - metabolism
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