Identification, Preparation, and Characterization of Several Polymorphs and Solvates of Terazosin Hydrochloride

The phenomenon of polymorphism is prevalent in pharmaceuticals, yet it is unusual to identify more than three or four forms for any particular drug. Terazosin hydrochloride has been found to exist at room temperature in four solvent-free forms that can be isolated directly, one solvent-free form tha...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2006-04, Vol.95 (4), p.917-928
Hauptverfasser:	Bauer, J., Morley, J., Spanton, S., Leusen, F.J.J., Henry, R., Hollis, S., Heitmann, W., Mannino, A., Quick, J., Dziki, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Biological and medical sciences Calorimetry, Differential Scanning Computer Simulation Crystallography, X-Ray dehydrate Drug Stability General pharmacology Humidity Magnetic Resonance Spectroscopy Medical sciences Methanol - chemistry methanolate Models, Molecular molecular modeling Molecular Structure Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase Transition polymorphs Prazosin - analogs & derivatives Prazosin - chemical synthesis Prazosin - chemistry Solvents - chemistry terazosin Water - chemistry X-ray diffraction
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