Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients
BACKGROUNDNumerous studies have shown a relationship between hyperhomocysteinemia, atherothrombosis and cardiovascular mortality. However, an association between hyperhomocysteinemia and the extent of coronary artery disease (CAD) remains controversial whereas its relationship with left ventricular...
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| Veröffentlicht in: | Coronary artery disease 2005-05, Vol.16 (3), p.153-161 |
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| creator | Bokhari, Syed W Bokhari, Zubaria W Zell, Jason A Lee, Don W Faxon, David P |
| description | BACKGROUNDNumerous studies have shown a relationship between hyperhomocysteinemia, atherothrombosis and cardiovascular mortality. However, an association between hyperhomocysteinemia and the extent of coronary artery disease (CAD) remains controversial whereas its relationship with left ventricular systolic function has not been established.
METHODSOne hundred and fifty-seven patients with angiographically defined CAD were included. The relationships between hyperhomocysteinemia, severity of CAD and left ventricular systolic function were studied. Left ventricular systolic function was determined primarily by ventriculography. The severity of CAD was determined through coronary angiography using the Gensini score and the number of vessels with ≥50% stenosis.
RESULTSThe mean fasting plasma homocysteine level was 13.4 μmol/l±0.5 SE. Elevated levels of homocysteine correlated significantly with increased severity of CAD both by the Gensini scores (r-value=0.344, P |
| doi_str_mv | 10.1097/00019501-200505000-00004 |
| format | Article |
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METHODSOne hundred and fifty-seven patients with angiographically defined CAD were included. The relationships between hyperhomocysteinemia, severity of CAD and left ventricular systolic function were studied. Left ventricular systolic function was determined primarily by ventriculography. The severity of CAD was determined through coronary angiography using the Gensini score and the number of vessels with ≥50% stenosis.
RESULTSThe mean fasting plasma homocysteine level was 13.4 μmol/l±0.5 SE. Elevated levels of homocysteine correlated significantly with increased severity of CAD both by the Gensini scores (r-value=0.344, P<0.0005) and the total number of diseased vessels (r-value=0.387, P<0.0005). The patients with hyperhomocysteinemia were found to have significantly reduced left ventricular ejection fraction (r-value=−0.382, P<0.0005). A multivariate regression analysis revealed homocysteine level to be an independent predictor of left ventricular systolic function. In addition, adjusted analysis revealed hyperhomocysteinemia to be associated with global left ventricular dysfunction.
CONCLUSIONIn patients with CAD, homocysteine levels correlate independently with left ventricular systolic function. The mechanism of this association between homocysteine and left ventricular systolic function is unknown but may be due to a direct effect of homocysteine on myocardial function separate from its effects on coronary atherosclerosis.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/00019501-200505000-00004</identifier><identifier>PMID: 15818084</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Aged ; Cholesterol, HDL - blood ; Continental Population Groups ; Coronary Artery Disease - blood ; Coronary Artery Disease - physiopathology ; Diabetes Mellitus, Type 1 - physiopathology ; Female ; Homocysteine - blood ; Humans ; Hyperhomocysteinemia - physiopathology ; Male ; Multivariate Analysis ; Severity of Illness Index ; Stroke Volume - physiology ; Systole - physiology ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Coronary artery disease, 2005-05, Vol.16 (3), p.153-161</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3584-4b5a15617cebdea60bfd9105b87cc16d21c3985fa6b6b190b62f37bc387393203</citedby><cites>FETCH-LOGICAL-c3584-4b5a15617cebdea60bfd9105b87cc16d21c3985fa6b6b190b62f37bc387393203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15818084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bokhari, Syed W</creatorcontrib><creatorcontrib>Bokhari, Zubaria W</creatorcontrib><creatorcontrib>Zell, Jason A</creatorcontrib><creatorcontrib>Lee, Don W</creatorcontrib><creatorcontrib>Faxon, David P</creatorcontrib><title>Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>BACKGROUNDNumerous studies have shown a relationship between hyperhomocysteinemia, atherothrombosis and cardiovascular mortality. However, an association between hyperhomocysteinemia and the extent of coronary artery disease (CAD) remains controversial whereas its relationship with left ventricular systolic function has not been established.
METHODSOne hundred and fifty-seven patients with angiographically defined CAD were included. The relationships between hyperhomocysteinemia, severity of CAD and left ventricular systolic function were studied. Left ventricular systolic function was determined primarily by ventriculography. The severity of CAD was determined through coronary angiography using the Gensini score and the number of vessels with ≥50% stenosis.
RESULTSThe mean fasting plasma homocysteine level was 13.4 μmol/l±0.5 SE. Elevated levels of homocysteine correlated significantly with increased severity of CAD both by the Gensini scores (r-value=0.344, P<0.0005) and the total number of diseased vessels (r-value=0.387, P<0.0005). The patients with hyperhomocysteinemia were found to have significantly reduced left ventricular ejection fraction (r-value=−0.382, P<0.0005). A multivariate regression analysis revealed homocysteine level to be an independent predictor of left ventricular systolic function. In addition, adjusted analysis revealed hyperhomocysteinemia to be associated with global left ventricular dysfunction.
CONCLUSIONIn patients with CAD, homocysteine levels correlate independently with left ventricular systolic function. The mechanism of this association between homocysteine and left ventricular systolic function is unknown but may be due to a direct effect of homocysteine on myocardial function separate from its effects on coronary atherosclerosis.</description><subject>Aged</subject><subject>Cholesterol, HDL - blood</subject><subject>Continental Population Groups</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - physiopathology</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Severity of Illness Index</subject><subject>Stroke Volume - physiology</subject><subject>Systole - physiology</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EotvCX0A-cUsZx585ooqPSpXKgZ4t25loDU682Emr_vu67AInZI1Glp7XIz9DCGVwyWDQHwCADRJY1wPIdgC6ViBekB0TmnfScHhJdjBI0amhN2fkvNYfLSSklq_JGZOGGTBiR-K35Ors6D7POTzWFeOCNOE9pkrdMtJ1_3ydVnqPy1pi2JIrtDYwpxjotC1hjXmhcaEhl7y48khdWbG1MVZ0FenBrbFl6xvyanKp4ttTvyB3nz99v_ra3dx-ub76eNMFLo3ohJeOScV0QD-iU-CncWAgvdEhMDX2LPDByMkprzwbwKt-4toHbjQfeA_8grw_vnso-deGdbVzrAFTcgvmrVqldc-EUQ00RzCUXGvByR5KnNsPLAP7rNn-0Wz_ara_Nbfou9OMzc84_guevDZAHIGHnJqN-jNtD1jsHl1a9_Z_6-NP05qJnA</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Bokhari, Syed W</creator><creator>Bokhari, Zubaria W</creator><creator>Zell, Jason A</creator><creator>Lee, Don W</creator><creator>Faxon, David P</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients</title><author>Bokhari, Syed W ; Bokhari, Zubaria W ; Zell, Jason A ; Lee, Don W ; Faxon, David P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3584-4b5a15617cebdea60bfd9105b87cc16d21c3985fa6b6b190b62f37bc387393203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Cholesterol, HDL - blood</topic><topic>Continental Population Groups</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - physiopathology</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Severity of Illness Index</topic><topic>Stroke Volume - physiology</topic><topic>Systole - physiology</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bokhari, Syed W</creatorcontrib><creatorcontrib>Bokhari, Zubaria W</creatorcontrib><creatorcontrib>Zell, Jason A</creatorcontrib><creatorcontrib>Lee, Don W</creatorcontrib><creatorcontrib>Faxon, David P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bokhari, Syed W</au><au>Bokhari, Zubaria W</au><au>Zell, Jason A</au><au>Lee, Don W</au><au>Faxon, David P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2005-05</date><risdate>2005</risdate><volume>16</volume><issue>3</issue><spage>153</spage><epage>161</epage><pages>153-161</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>BACKGROUNDNumerous studies have shown a relationship between hyperhomocysteinemia, atherothrombosis and cardiovascular mortality. However, an association between hyperhomocysteinemia and the extent of coronary artery disease (CAD) remains controversial whereas its relationship with left ventricular systolic function has not been established.
METHODSOne hundred and fifty-seven patients with angiographically defined CAD were included. The relationships between hyperhomocysteinemia, severity of CAD and left ventricular systolic function were studied. Left ventricular systolic function was determined primarily by ventriculography. The severity of CAD was determined through coronary angiography using the Gensini score and the number of vessels with ≥50% stenosis.
RESULTSThe mean fasting plasma homocysteine level was 13.4 μmol/l±0.5 SE. Elevated levels of homocysteine correlated significantly with increased severity of CAD both by the Gensini scores (r-value=0.344, P<0.0005) and the total number of diseased vessels (r-value=0.387, P<0.0005). The patients with hyperhomocysteinemia were found to have significantly reduced left ventricular ejection fraction (r-value=−0.382, P<0.0005). A multivariate regression analysis revealed homocysteine level to be an independent predictor of left ventricular systolic function. In addition, adjusted analysis revealed hyperhomocysteinemia to be associated with global left ventricular dysfunction.
CONCLUSIONIn patients with CAD, homocysteine levels correlate independently with left ventricular systolic function. The mechanism of this association between homocysteine and left ventricular systolic function is unknown but may be due to a direct effect of homocysteine on myocardial function separate from its effects on coronary atherosclerosis.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15818084</pmid><doi>10.1097/00019501-200505000-00004</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Cholesterol, HDL - blood Continental Population Groups Coronary Artery Disease - blood Coronary Artery Disease - physiopathology Diabetes Mellitus, Type 1 - physiopathology Female Homocysteine - blood Humans Hyperhomocysteinemia - physiopathology Male Multivariate Analysis Severity of Illness Index Stroke Volume - physiology Systole - physiology Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - physiopathology |
| title | Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients |
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