Soluble endothelial protein C receptor (sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants

The role of the A3 haplotype and soluble endothelial protein C receptor (sEPCR) plasma levels in predisposing the carriers of two peculiar dysfunctional protein C (PC) variants (PC Arg-1→Cys and PC Arg-1→Leu, also known as PC Padua 2 and PC Padua 3, respectively) to venous thromboembolism (VTE) has...

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Veröffentlicht in:	Thrombosis research 2006, Vol.117 (5), p.523-528
Hauptverfasser:	Simioni, Paolo, Morboeuf, Olivier, Tognin, Giulio, Gavasso, Sabrina, Tormene, Daniela, Woodhams, Barry, Pagnan, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	A3 haplotype Adult Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Coagulation Factors Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Child Child, Preschool Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dysfunctional PC Enzyme-Linked Immunosorbent Assay EPCR gene Female Follow-Up Studies Genetic Predisposition to Disease Genetic Variation Haplotypes HLA-A3 Antigen - genetics Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Protein C - genetics Receptors, Cell Surface - blood Risk sEPCR levels Solubility Thrombophilia Venous Thrombosis - blood Venous Thrombosis - diagnosis Venous Thrombosis - genetics
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