Superoxide enhances Na-K-2Cl cotransporter activity in the thick ascending limb

Superoxide (O2-) enhances Na reabsorption by the thick ascending limb (THAL). Na absorption in this segment involves the Na-K-2Cl cotransporter, K channel, and Na-K-ATPase. We hypothesized that O2- stimulates NaCl absorption primarily by enhancing Na-K-2Cl cotransport. First, we measured steady-stat...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2005-05, Vol.288 (5), p.F982-F987
Hauptverfasser:	Juncos, Ramiro, Garvin, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Polarity - physiology Enzyme Activation - physiology Loop of Henle - cytology Loop of Henle - metabolism Male Rats Rats, Sprague-Dawley Sodium - metabolism Sodium-Potassium-Chloride Symporters - metabolism Solute Carrier Family 12, Member 1 Superoxides - metabolism
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