Direct and indirect effects of estrogen on rat hippocampus

Estrogen-induced synaptic plasticity was frequently shown by an increase of spines at apical dendrites of CA1 pyramidal neurons after systemic application of estradiol to ovariectomized rats. Recent findings question this direct endocrine regulation of synaptogenesis by estradiol. We have shown, for...

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Veröffentlicht in:	Neuroscience 2006-01, Vol.138 (3), p.765-772
Hauptverfasser:	Prange-Kiel, J., Rune, G.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aromatase Biological and medical sciences Dendrites - physiology endogenous estradiol Estradiol - biosynthesis Estradiol - pharmacology Estrogens - biosynthesis Estrogens - pharmacology Estrogens - physiology Female Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiology letrozole Nerve Tissue Proteins - metabolism Ovariectomy Pyramidal Cells - physiology Rats Receptors, Estrogen - physiology subcortical nuclei Synapses - physiology synaptic plasticity Vertebrates: nervous system and sense organs
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