Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension
A 37-yr-old man presented with the classic signs of mineralocorticoid excess hypertension and hypokalemia. The cause was not aldosterone excess, but elevation of plasma 11-deoxycorticosterone (DOC). Computed tomography (CT) scans showed a large right adrenal mass without signs of metastatic disease....
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| Veröffentlicht in: | Journal of endocrinological investigation 2005-01, Vol.28 (1), p.61-65 |
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| creator | Müssig, K Wehrmann, M Horger, M Maser-Gluth, C Häring, H U Overkamp, D |
| description | A 37-yr-old man presented with the classic signs of mineralocorticoid excess hypertension and hypokalemia. The cause was not aldosterone excess, but elevation of plasma 11-deoxycorticosterone (DOC). Computed tomography (CT) scans showed a large right adrenal mass without signs of metastatic disease. The tumor was removed by open laparotomy, and histology revealed an adrenocortical carcinoma. Two yr after diagnosis, the patient is in good general condition and there is no sign of recurrence or metastatic disease, despite the large tumor size. DOC producing adrenocortical carcinomas causing mineralocorticoid hypertension are very rare, so far only 10 cases have been described in the literature. |
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The cause was not aldosterone excess, but elevation of plasma 11-deoxycorticosterone (DOC). Computed tomography (CT) scans showed a large right adrenal mass without signs of metastatic disease. The tumor was removed by open laparotomy, and histology revealed an adrenocortical carcinoma. Two yr after diagnosis, the patient is in good general condition and there is no sign of recurrence or metastatic disease, despite the large tumor size. DOC producing adrenocortical carcinomas causing mineralocorticoid hypertension are very rare, so far only 10 cases have been described in the literature.</description><identifier>ISSN: 0391-4097</identifier><identifier>PMID: 15816373</identifier><language>eng</language><publisher>Italy</publisher><subject>Adrenal Cortex Hormones - blood ; Adrenal Cortex Hormones - urine ; Adrenal Cortex Neoplasms - diagnostic imaging ; Adrenal Cortex Neoplasms - metabolism ; Adrenal Cortex Neoplasms - surgery ; Adrenalectomy ; Adult ; Aldosterone - blood ; Aldosterone - urine ; Catecholamines - urine ; Desoxycorticosterone - biosynthesis ; Humans ; Hypertension - etiology ; Hypertension - physiopathology ; Hypokalemia - etiology ; Hypokalemia - physiopathology ; Male ; Mineralocorticoids - physiology ; Pheochromocytoma - diagnostic imaging ; Pheochromocytoma - metabolism ; Pheochromocytoma - surgery ; Renin - blood ; Tomography, X-Ray Computed</subject><ispartof>Journal of endocrinological investigation, 2005-01, Vol.28 (1), p.61-65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15816373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Müssig, K</creatorcontrib><creatorcontrib>Wehrmann, M</creatorcontrib><creatorcontrib>Horger, M</creatorcontrib><creatorcontrib>Maser-Gluth, C</creatorcontrib><creatorcontrib>Häring, H U</creatorcontrib><creatorcontrib>Overkamp, D</creatorcontrib><title>Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>A 37-yr-old man presented with the classic signs of mineralocorticoid excess hypertension and hypokalemia. The cause was not aldosterone excess, but elevation of plasma 11-deoxycorticosterone (DOC). Computed tomography (CT) scans showed a large right adrenal mass without signs of metastatic disease. The tumor was removed by open laparotomy, and histology revealed an adrenocortical carcinoma. Two yr after diagnosis, the patient is in good general condition and there is no sign of recurrence or metastatic disease, despite the large tumor size. DOC producing adrenocortical carcinomas causing mineralocorticoid hypertension are very rare, so far only 10 cases have been described in the literature.</description><subject>Adrenal Cortex Hormones - blood</subject><subject>Adrenal Cortex Hormones - urine</subject><subject>Adrenal Cortex Neoplasms - diagnostic imaging</subject><subject>Adrenal Cortex Neoplasms - metabolism</subject><subject>Adrenal Cortex Neoplasms - surgery</subject><subject>Adrenalectomy</subject><subject>Adult</subject><subject>Aldosterone - blood</subject><subject>Aldosterone - urine</subject><subject>Catecholamines - urine</subject><subject>Desoxycorticosterone - biosynthesis</subject><subject>Humans</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Hypokalemia - etiology</subject><subject>Hypokalemia - physiopathology</subject><subject>Male</subject><subject>Mineralocorticoids - physiology</subject><subject>Pheochromocytoma - diagnostic imaging</subject><subject>Pheochromocytoma - metabolism</subject><subject>Pheochromocytoma - surgery</subject><subject>Renin - blood</subject><subject>Tomography, X-Ray Computed</subject><issn>0391-4097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAQhnNQ3HX1L0hO3goZ0jaNt2XxCxa86LlMk4lG2qQmLdh_b2HX07wDzzzwzgXbCqmhKIVWG3ad87cQUslGXbENVA3U67Jlfm8ThWhimrzBnhtMxoc4IB9TtPOaPzlAYSn-Lico5olSDPTAkSdMtJ7MmXh0fPCBEvZnWfSWfy0jpYlC9jHcsEuHfabb89yxj6fH98NLcXx7fj3sj8UIUk-FKivXuBpEp5xUppakBWhSoCusNDrdNLZUAECdpbIRWBmFoDt0Xemk03LH7k_etcDPTHlqB58N9T0GinNua7W6hBQreHcG524g247JD5iW9v858g9kyGIk</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Müssig, K</creator><creator>Wehrmann, M</creator><creator>Horger, M</creator><creator>Maser-Gluth, C</creator><creator>Häring, H U</creator><creator>Overkamp, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension</title><author>Müssig, K ; Wehrmann, M ; Horger, M ; Maser-Gluth, C ; Häring, H U ; Overkamp, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-745f8f610b7f37c63e9019e7195a59af988d47111ebde480a5c7a19bafb4f3f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenal Cortex Hormones - blood</topic><topic>Adrenal Cortex Hormones - urine</topic><topic>Adrenal Cortex Neoplasms - diagnostic imaging</topic><topic>Adrenal Cortex Neoplasms - metabolism</topic><topic>Adrenal Cortex Neoplasms - surgery</topic><topic>Adrenalectomy</topic><topic>Adult</topic><topic>Aldosterone - blood</topic><topic>Aldosterone - urine</topic><topic>Catecholamines - urine</topic><topic>Desoxycorticosterone - biosynthesis</topic><topic>Humans</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Hypokalemia - etiology</topic><topic>Hypokalemia - physiopathology</topic><topic>Male</topic><topic>Mineralocorticoids - physiology</topic><topic>Pheochromocytoma - diagnostic imaging</topic><topic>Pheochromocytoma - metabolism</topic><topic>Pheochromocytoma - surgery</topic><topic>Renin - blood</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müssig, K</creatorcontrib><creatorcontrib>Wehrmann, M</creatorcontrib><creatorcontrib>Horger, M</creatorcontrib><creatorcontrib>Maser-Gluth, C</creatorcontrib><creatorcontrib>Häring, H U</creatorcontrib><creatorcontrib>Overkamp, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müssig, K</au><au>Wehrmann, M</au><au>Horger, M</au><au>Maser-Gluth, C</au><au>Häring, H U</au><au>Overkamp, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>2005-01</date><risdate>2005</risdate><volume>28</volume><issue>1</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0391-4097</issn><abstract>A 37-yr-old man presented with the classic signs of mineralocorticoid excess hypertension and hypokalemia. 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| subjects | Adrenal Cortex Hormones - blood Adrenal Cortex Hormones - urine Adrenal Cortex Neoplasms - diagnostic imaging Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - surgery Adrenalectomy Adult Aldosterone - blood Aldosterone - urine Catecholamines - urine Desoxycorticosterone - biosynthesis Humans Hypertension - etiology Hypertension - physiopathology Hypokalemia - etiology Hypokalemia - physiopathology Male Mineralocorticoids - physiology Pheochromocytoma - diagnostic imaging Pheochromocytoma - metabolism Pheochromocytoma - surgery Renin - blood Tomography, X-Ray Computed |
| title | Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension |
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