Effect of cyclodextrins on α-chymotrypsin stability and loading in PLGA microspheres upon S/O/W encapsulation

The potential of cyclodextrins to stabilize α-chymotrypsin upon encapsulation in Poly(lactic-co-glycolic) acid (PLGA) microspheres using a solid-in-oil-in-water (s/o/w) technique was investigated. Two cyclodextrins, hydroxyl-propyl-β-cyclodextrin (HPβCD) and methyl-β-cyclodextrin (MβCD), one insolub...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2006-04, Vol.95 (4), p.849-858
Hauptverfasser:	Castellanos, Ingrid J., Flores, Giselle, Griebenow, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin beta-Cyclodextrins - chemistry Biological and medical sciences Chymotrypsin - chemistry cyclodextrins Drug Compounding - methods Emulsions Enzyme Stability - drug effects Excipients - chemistry Excipients - pharmacology General pharmacology Lactic Acid - chemistry Medical sciences Methylene Chloride - chemistry Microspheres Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyglycolic Acid - chemistry Polymers - chemistry protein aggregation protein stabilization solid-in-oil-in-water (s/o/w) encapsulation procedure Solvents - chemistry Surface Properties Water - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!