The differential diagnosis of acute transverse myelitis
The clinical and paraclinical characteristics of acute transverse myelitis (ATM) were analyzed in 31 patients. In some patients there was clinical evidence of complete transection, in others of only partial lesions. Magnetic resonance imaging (MRI) in the acute phase in the first group was normal, b...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2006-03, Vol.108 (3), p.278-283 |
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| creator | Brinar, Vesna V. Habek, Mario Brinar, Marko Malojčić, Branko Boban, Marina |
| description | The clinical and paraclinical characteristics of acute transverse myelitis (ATM) were analyzed in 31 patients. In some patients there was clinical evidence of complete transection, in others of only partial lesions. Magnetic resonance imaging (MRI) in the acute phase in the first group was normal, but showed cord atrophy subsequently. It is probable that the clinical picture was due to parenchymatous neuronal lesions, analogous to those of axonal polyneuropathy. In the patients with incomplete transverse lesions, the most common finding was demyelination. In the patients with circumscribed demyelinating lesions, the symptoms and MRI were suggestive of clinically isolated syndromes (CIS) predictive of multiple sclerosis (MS). Extensive demyelination was indicative of acute disseminated encephalomyelitis (ADEM) due to hyperergic vasculopathy or various forms of chronic vasculitis. In two patients with variable clinical symptoms, a vascular malformation was the cause of the clinical presentation, and in one patient demyelination was due to the disc compression. |
| doi_str_mv | 10.1016/j.clineuro.2005.11.008 |
| format | Article |
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In some patients there was clinical evidence of complete transection, in others of only partial lesions. Magnetic resonance imaging (MRI) in the acute phase in the first group was normal, but showed cord atrophy subsequently. It is probable that the clinical picture was due to parenchymatous neuronal lesions, analogous to those of axonal polyneuropathy. In the patients with incomplete transverse lesions, the most common finding was demyelination. In the patients with circumscribed demyelinating lesions, the symptoms and MRI were suggestive of clinically isolated syndromes (CIS) predictive of multiple sclerosis (MS). Extensive demyelination was indicative of acute disseminated encephalomyelitis (ADEM) due to hyperergic vasculopathy or various forms of chronic vasculitis. In two patients with variable clinical symptoms, a vascular malformation was the cause of the clinical presentation, and in one patient demyelination was due to the disc compression.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2005.11.008</identifier><identifier>PMID: 16376014</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brain - pathology ; Cervical Vertebrae ; Clinically isolated syndrome ; Diagnosis, Differential ; Disseminated encephalomyelitis ; Encephalomyelitis, Acute Disseminated - complications ; Encephalomyelitis, Acute Disseminated - diagnosis ; Encephalomyelitis, Acute Disseminated - physiopathology ; Evoked Potentials, Visual - physiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - physiopathology ; Myelitis, Transverse - diagnosis ; Myelitis, Transverse - etiology ; Myelitis, Transverse - physiopathology ; Neurology ; Neurosurgery ; Retrospective Studies ; Spinal Cord - pathology ; Surgery (general aspects). 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In some patients there was clinical evidence of complete transection, in others of only partial lesions. Magnetic resonance imaging (MRI) in the acute phase in the first group was normal, but showed cord atrophy subsequently. It is probable that the clinical picture was due to parenchymatous neuronal lesions, analogous to those of axonal polyneuropathy. In the patients with incomplete transverse lesions, the most common finding was demyelination. In the patients with circumscribed demyelinating lesions, the symptoms and MRI were suggestive of clinically isolated syndromes (CIS) predictive of multiple sclerosis (MS). Extensive demyelination was indicative of acute disseminated encephalomyelitis (ADEM) due to hyperergic vasculopathy or various forms of chronic vasculitis. In two patients with variable clinical symptoms, a vascular malformation was the cause of the clinical presentation, and in one patient demyelination was due to the disc compression.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cervical Vertebrae</subject><subject>Clinically isolated syndrome</subject><subject>Diagnosis, Differential</subject><subject>Disseminated encephalomyelitis</subject><subject>Encephalomyelitis, Acute Disseminated - complications</subject><subject>Encephalomyelitis, Acute Disseminated - diagnosis</subject><subject>Encephalomyelitis, Acute Disseminated - physiopathology</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Myelitis, Transverse - diagnosis</subject><subject>Myelitis, Transverse - etiology</subject><subject>Myelitis, Transverse - physiopathology</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Retrospective Studies</subject><subject>Spinal Cord - pathology</subject><subject>Surgery (general aspects). 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Graft diseases</subject><subject>Thoracic Vertebrae</subject><subject>Transverse myelitis</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0E1rGzEQgGFRGhrn4y-EhdLcdjP6lm8tpmkKhl58F7I0SmTWu660a8i_r4JdAr30JATPDMNLyB2FjgJVD7vO92nAOY8dA5AdpR2A-UAW1GjWqqUyH8kCOPDWCKUvyVUpOwDgXJlP5JIqrhVQsSB684JNSDFixmFKrq8f9zyMJZVmjI3z84TNlN1QjpgLNvtX7NOUyg25iK4veHt-r8nm8ftm9dSuf_34ufq2br1gYmp1WDIdIncgApfb6IJUMXIJGrkBr6N33kkttsowJgNQsw1ggDMJSjDNr8n9ae0hj79nLJPdp-Kx792A41ys0poaRkWFn_-Bu3HOQz3N0rpOy6UQUJU6KZ_HUjJGe8hp7_JrRfatq93Zv13tW1dLqa1d6-Ddef283WN4HzuHrODLGbjiXR9rMZ_Ku9NKSkFZdV9PDmu0Y8Jsi084eAwpo59sGNP_bvkDSBqYUQ</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Brinar, Vesna V.</creator><creator>Habek, Mario</creator><creator>Brinar, Marko</creator><creator>Malojčić, Branko</creator><creator>Boban, Marina</creator><general>Elsevier B.V</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>The differential diagnosis of acute transverse myelitis</title><author>Brinar, Vesna V. ; Habek, Mario ; Brinar, Marko ; Malojčić, Branko ; Boban, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-7d927df3a04d35bfad56ff3507e380c7fcaca574b68225d018bd080325064273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Cervical Vertebrae</topic><topic>Clinically isolated syndrome</topic><topic>Diagnosis, Differential</topic><topic>Disseminated encephalomyelitis</topic><topic>Encephalomyelitis, Acute Disseminated - complications</topic><topic>Encephalomyelitis, Acute Disseminated - diagnosis</topic><topic>Encephalomyelitis, Acute Disseminated - physiopathology</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Myelitis, Transverse - diagnosis</topic><topic>Myelitis, Transverse - etiology</topic><topic>Myelitis, Transverse - physiopathology</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Retrospective Studies</topic><topic>Spinal Cord - pathology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Thoracic Vertebrae</topic><topic>Transverse myelitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brinar, Vesna V.</creatorcontrib><creatorcontrib>Habek, Mario</creatorcontrib><creatorcontrib>Brinar, Marko</creatorcontrib><creatorcontrib>Malojčić, Branko</creatorcontrib><creatorcontrib>Boban, Marina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brinar, Vesna V.</au><au>Habek, Mario</au><au>Brinar, Marko</au><au>Malojčić, Branko</au><au>Boban, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The differential diagnosis of acute transverse myelitis</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>108</volume><issue>3</issue><spage>278</spage><epage>283</epage><pages>278-283</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><coden>CNNSBV</coden><abstract>The clinical and paraclinical characteristics of acute transverse myelitis (ATM) were analyzed in 31 patients. In some patients there was clinical evidence of complete transection, in others of only partial lesions. Magnetic resonance imaging (MRI) in the acute phase in the first group was normal, but showed cord atrophy subsequently. It is probable that the clinical picture was due to parenchymatous neuronal lesions, analogous to those of axonal polyneuropathy. In the patients with incomplete transverse lesions, the most common finding was demyelination. In the patients with circumscribed demyelinating lesions, the symptoms and MRI were suggestive of clinically isolated syndromes (CIS) predictive of multiple sclerosis (MS). Extensive demyelination was indicative of acute disseminated encephalomyelitis (ADEM) due to hyperergic vasculopathy or various forms of chronic vasculitis. In two patients with variable clinical symptoms, a vascular malformation was the cause of the clinical presentation, and in one patient demyelination was due to the disc compression.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16376014</pmid><doi>10.1016/j.clineuro.2005.11.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Brain - pathology Cervical Vertebrae Clinically isolated syndrome Diagnosis, Differential Disseminated encephalomyelitis Encephalomyelitis, Acute Disseminated - complications Encephalomyelitis, Acute Disseminated - diagnosis Encephalomyelitis, Acute Disseminated - physiopathology Evoked Potentials, Visual - physiology Female Humans Male Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - diagnosis Multiple Sclerosis - physiopathology Myelitis, Transverse - diagnosis Myelitis, Transverse - etiology Myelitis, Transverse - physiopathology Neurology Neurosurgery Retrospective Studies Spinal Cord - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thoracic Vertebrae Transverse myelitis |
| title | The differential diagnosis of acute transverse myelitis |
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