SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population

Serum triglyceride levels (TG) are important independent risk factors for coronary heart disease. The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG > 9 mmol/l) and controls...

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Veröffentlicht in:	Atherosclerosis 2006-04, Vol.185 (2), p.353-360
Hauptverfasser:	Wright, William T., Young, Ian S., Nicholls, D. Paul, Patterson, Chris, Lyttle, Kelly, Graham, Colin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	APOA5 APOC3 Apolipoprotein A-I - genetics Apolipoprotein A-V Apolipoprotein C-III Apolipoproteins - genetics Apolipoproteins A - genetics Apolipoproteins C - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chromosomes, Human, Pair 11 Diseases of the cardiovascular system Female Fundamental and applied biological sciences. Psychology General aspects Genetics Genotype Haplotypes Humans Hypertriglyceridaemia Hypertriglyceridemia - blood Hypertriglyceridemia - genetics Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sequence Analysis, DNA Triglycerides - blood Vertebrates: cardiovascular system
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