SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population
Serum triglyceride levels (TG) are important independent risk factors for coronary heart disease. The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG > 9 mmol/l) and controls...
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| Veröffentlicht in: | Atherosclerosis 2006-04, Vol.185 (2), p.353-360 |
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| creator | Wright, William T. Young, Ian S. Nicholls, D. Paul Patterson, Chris Lyttle, Kelly Graham, Colin A. |
| description | Serum triglyceride levels (TG) are important independent risk factors for coronary heart disease. The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG
>
9
mmol/l) and controls (TG
<
2
mmol/l). A total of 53 SNPs were identified in these genes with 17 being novel to this study. Further analysis defined four
APOC3 SNPs and three
APOA5 SNPs showing strong association with TG levels. Analysis of the two major SNPs from
APOA5 [c.56C
>
G, c.-3A
>
G] and from
APOC3 [c.102C
>
T, c.340C
>
G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26). Logistic regression analysis of these four SNPs revealed that, carriage of the
APOA5 c.56 G allele (odd ratios 4.49) and the
APOA5 c.-3 G allele (odds ratio 3.23) were strong independent predictors of hypertriglyceridaemia (
P
<
0.001), whereas in contrast, carriage of the
APOC3 c102 T allele (odds ratio 1.35) and the
APOC3 c.340 G allele (odds ratio 1.37), did not show any significant effects that were independent of
APOA5. |
| doi_str_mv | 10.1016/j.atherosclerosis.2005.06.043 |
| format | Article |
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>
9
mmol/l) and controls (TG
<
2
mmol/l). A total of 53 SNPs were identified in these genes with 17 being novel to this study. Further analysis defined four
APOC3 SNPs and three
APOA5 SNPs showing strong association with TG levels. Analysis of the two major SNPs from
APOA5 [c.56C
>
G, c.-3A
>
G] and from
APOC3 [c.102C
>
T, c.340C
>
G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26). Logistic regression analysis of these four SNPs revealed that, carriage of the
APOA5 c.56 G allele (odd ratios 4.49) and the
APOA5 c.-3 G allele (odds ratio 3.23) were strong independent predictors of hypertriglyceridaemia (
P
<
0.001), whereas in contrast, carriage of the
APOC3 c102 T allele (odds ratio 1.35) and the
APOC3 c.340 G allele (odds ratio 1.37), did not show any significant effects that were independent of
APOA5.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2005.06.043</identifier><identifier>PMID: 16125709</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>APOA5 ; APOC3 ; Apolipoprotein A-I - genetics ; Apolipoprotein A-V ; Apolipoprotein C-III ; Apolipoproteins - genetics ; Apolipoproteins A - genetics ; Apolipoproteins C - genetics ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Chromosomes, Human, Pair 11 ; Diseases of the cardiovascular system ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Genetics ; Genotype ; Haplotypes ; Humans ; Hypertriglyceridaemia ; Hypertriglyceridemia - blood ; Hypertriglyceridemia - genetics ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Sequence Analysis, DNA ; Triglycerides - blood ; Vertebrates: cardiovascular system</subject><ispartof>Atherosclerosis, 2006-04, Vol.185 (2), p.353-360</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d8a7d3ed44e5e6e6dfd0d5e16264e22399c2a653170035762c15ca2c52b568ae3</citedby><cites>FETCH-LOGICAL-c417t-d8a7d3ed44e5e6e6dfd0d5e16264e22399c2a653170035762c15ca2c52b568ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2005.06.043$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17582405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16125709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, William T.</creatorcontrib><creatorcontrib>Young, Ian S.</creatorcontrib><creatorcontrib>Nicholls, D. Paul</creatorcontrib><creatorcontrib>Patterson, Chris</creatorcontrib><creatorcontrib>Lyttle, Kelly</creatorcontrib><creatorcontrib>Graham, Colin A.</creatorcontrib><title>SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Serum triglyceride levels (TG) are important independent risk factors for coronary heart disease. The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG
>
9
mmol/l) and controls (TG
<
2
mmol/l). A total of 53 SNPs were identified in these genes with 17 being novel to this study. Further analysis defined four
APOC3 SNPs and three
APOA5 SNPs showing strong association with TG levels. Analysis of the two major SNPs from
APOA5 [c.56C
>
G, c.-3A
>
G] and from
APOC3 [c.102C
>
T, c.340C
>
G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26). Logistic regression analysis of these four SNPs revealed that, carriage of the
APOA5 c.56 G allele (odd ratios 4.49) and the
APOA5 c.-3 G allele (odds ratio 3.23) were strong independent predictors of hypertriglyceridaemia (
P
<
0.001), whereas in contrast, carriage of the
APOC3 c102 T allele (odds ratio 1.35) and the
APOC3 c.340 G allele (odds ratio 1.37), did not show any significant effects that were independent of
APOA5.</description><subject>APOA5</subject><subject>APOC3</subject><subject>Apolipoprotein A-I - genetics</subject><subject>Apolipoprotein A-V</subject><subject>Apolipoprotein C-III</subject><subject>Apolipoproteins - genetics</subject><subject>Apolipoproteins A - genetics</subject><subject>Apolipoproteins C - genetics</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Hypertriglyceridaemia</subject><subject>Hypertriglyceridemia - blood</subject><subject>Hypertriglyceridemia - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Sequence Analysis, DNA</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: cardiovascular system</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EokPhFZA3ZZcZ2_ElWbAYjaBUqtpKwNpy7ZOJR0mc2knRvBGPieciEKzY-Cz8_b8vH0JXlCwpoXK1W5qphRiS7Q6rT0tGiFgSuSS8fIEWtFJ1QXnFX6IFIYwWNRXkAr1JaUcI4YpWr9EFlZQJReoF-vn17iFhM-FcitcP92uBtzAANtaGeZhwE-JxK00xDFtsUgrWm8mHAf_wU4vb_Qhxin7b7S1E7wz03vzVt8JrvsKbMk-Ku2DnhHPYtjH0IYUeMKVPrMR-OEbuQjw8b8A30acWj2Gcu-Nxb9GrxnQJ3p3nJfr--dO3zZfi9v76ZrO-LSynaipcZZQrwXEOAiRI1zjiBFDJJAfGyrq2zEhRUkVIKZRklgprmBXsUcjKQHmJPpx6xxieZkiT7n2y0HVmgDAnLZWiOaYy-PEE2qwhRWj0GH1v4l5Tog-q9E7_o0ofVGkidVaV8-_PB82PPbg_6bObDFydAZOs6ZpoBps7fnNKVIwTkbnrEwf5W549RJ2sh8GC8xHspF3w_3mlX7iDu7Y</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Wright, William T.</creator><creator>Young, Ian S.</creator><creator>Nicholls, D. Paul</creator><creator>Patterson, Chris</creator><creator>Lyttle, Kelly</creator><creator>Graham, Colin A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population</title><author>Wright, William T. ; Young, Ian S. ; Nicholls, D. Paul ; Patterson, Chris ; Lyttle, Kelly ; Graham, Colin A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d8a7d3ed44e5e6e6dfd0d5e16264e22399c2a653170035762c15ca2c52b568ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>APOA5</topic><topic>APOC3</topic><topic>Apolipoprotein A-I - genetics</topic><topic>Apolipoprotein A-V</topic><topic>Apolipoprotein C-III</topic><topic>Apolipoproteins - genetics</topic><topic>Apolipoproteins A - genetics</topic><topic>Apolipoproteins C - genetics</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Chromosomes, Human, Pair 11</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Hypertriglyceridaemia</topic><topic>Hypertriglyceridemia - blood</topic><topic>Hypertriglyceridemia - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Sequence Analysis, DNA</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, William T.</creatorcontrib><creatorcontrib>Young, Ian S.</creatorcontrib><creatorcontrib>Nicholls, D. Paul</creatorcontrib><creatorcontrib>Patterson, Chris</creatorcontrib><creatorcontrib>Lyttle, Kelly</creatorcontrib><creatorcontrib>Graham, Colin A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, William T.</au><au>Young, Ian S.</au><au>Nicholls, D. Paul</au><au>Patterson, Chris</au><au>Lyttle, Kelly</au><au>Graham, Colin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>185</volume><issue>2</issue><spage>353</spage><epage>360</epage><pages>353-360</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Serum triglyceride levels (TG) are important independent risk factors for coronary heart disease. The apolipoproteins C-III (apoCIII) and A-V (apoAV) are central to normal TG metabolism and the complete sequence analysis of these genes was carried out in severe cases (TG
>
9
mmol/l) and controls (TG
<
2
mmol/l). A total of 53 SNPs were identified in these genes with 17 being novel to this study. Further analysis defined four
APOC3 SNPs and three
APOA5 SNPs showing strong association with TG levels. Analysis of the two major SNPs from
APOA5 [c.56C
>
G, c.-3A
>
G] and from
APOC3 [c.102C
>
T, c.340C
>
G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26). Logistic regression analysis of these four SNPs revealed that, carriage of the
APOA5 c.56 G allele (odd ratios 4.49) and the
APOA5 c.-3 G allele (odds ratio 3.23) were strong independent predictors of hypertriglyceridaemia (
P
<
0.001), whereas in contrast, carriage of the
APOC3 c102 T allele (odds ratio 1.35) and the
APOC3 c.340 G allele (odds ratio 1.37), did not show any significant effects that were independent of
APOA5.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>16125709</pmid><doi>10.1016/j.atherosclerosis.2005.06.043</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Atherosclerosis, 2006-04, Vol.185 (2), p.353-360 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | APOA5 APOC3 Apolipoprotein A-I - genetics Apolipoprotein A-V Apolipoprotein C-III Apolipoproteins - genetics Apolipoproteins A - genetics Apolipoproteins C - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chromosomes, Human, Pair 11 Diseases of the cardiovascular system Female Fundamental and applied biological sciences. Psychology General aspects Genetics Genotype Haplotypes Humans Hypertriglyceridaemia Hypertriglyceridemia - blood Hypertriglyceridemia - genetics Male Medical sciences Middle Aged Polymorphism, Single Nucleotide Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sequence Analysis, DNA Triglycerides - blood Vertebrates: cardiovascular system |
| title | SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/ A4/ C3/ A1 locus on chromosome 11q23 in the Northern Irish population |
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