Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?

Background  Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin res...

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Veröffentlicht in:European journal of clinical investigation 2005-04, Vol.35 (4), p.265-270
Hauptverfasser: Bo, S., Gambino, R., Uberti, B., Mangiameli, M. P., Colosso, G., Repetti, E., Gentile, L., Cassader, M., Pagano, G. F.
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container_end_page 270
container_issue 4
container_start_page 265
container_title European journal of clinical investigation
container_volume 35
creator Bo, S.
Gambino, R.
Uberti, B.
Mangiameli, M. P.
Colosso, G.
Repetti, E.
Gentile, L.
Cassader, M.
Pagano, G. F.
description Background  Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects. Design  Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia. Results  In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile. Conclusions  The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.
doi_str_mv 10.1111/j.1365-2362.2005.01490.x
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P. ; Colosso, G. ; Repetti, E. ; Gentile, L. ; Cassader, M. ; Pagano, G. F.</creator><creatorcontrib>Bo, S. ; Gambino, R. ; Uberti, B. ; Mangiameli, M. P. ; Colosso, G. ; Repetti, E. ; Gentile, L. ; Cassader, M. ; Pagano, G. F.</creatorcontrib><description>Background  Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects. Design  Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia. Results  In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile. Conclusions  The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2005.01490.x</identifier><identifier>PMID: 15816996</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Cohort Studies ; Female ; General aspects ; Homeostasis ; Humans ; Insulin - blood ; Insulin Resistance ; Male ; Medical sciences ; Metabolic diseases ; metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - diagnosis ; Middle Aged ; Miscellaneous ; normal body mass index ; Other metabolic disorders</subject><ispartof>European journal of clinical investigation, 2005-04, Vol.35 (4), p.265-270</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Apr 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5280-24e55d39ca5b0e1ebf7b98a77669cda5bab62798d1c16340f7236e68c373e21c3</citedby><cites>FETCH-LOGICAL-c5280-24e55d39ca5b0e1ebf7b98a77669cda5bab62798d1c16340f7236e68c373e21c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2362.2005.01490.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2362.2005.01490.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16712770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15816996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bo, S.</creatorcontrib><creatorcontrib>Gambino, R.</creatorcontrib><creatorcontrib>Uberti, B.</creatorcontrib><creatorcontrib>Mangiameli, M. 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Design  Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia. Results  In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). 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P.</au><au>Colosso, G.</au><au>Repetti, E.</au><au>Gentile, L.</au><au>Cassader, M.</au><au>Pagano, G. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2005-04</date><risdate>2005</risdate><volume>35</volume><issue>4</issue><spage>265</spage><epage>270</epage><pages>265-270</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background  Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects. Design  Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia. Results  In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). 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subjects Biological and medical sciences
Body Mass Index
C-reactive protein
C-Reactive Protein - analysis
Cohort Studies
Female
General aspects
Homeostasis
Humans
Insulin - blood
Insulin Resistance
Male
Medical sciences
Metabolic diseases
metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - diagnosis
Middle Aged
Miscellaneous
normal body mass index
Other metabolic disorders
title Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?
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