Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?
Background Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin res...
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Veröffentlicht in: | European journal of clinical investigation 2005-04, Vol.35 (4), p.265-270 |
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description | Background Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects.
Design Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia.
Results In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile.
Conclusions The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities. |
doi_str_mv | 10.1111/j.1365-2362.2005.01490.x |
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Design Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia.
Results In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile.
Conclusions The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2005.01490.x</identifier><identifier>PMID: 15816996</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Cohort Studies ; Female ; General aspects ; Homeostasis ; Humans ; Insulin - blood ; Insulin Resistance ; Male ; Medical sciences ; Metabolic diseases ; metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - diagnosis ; Middle Aged ; Miscellaneous ; normal body mass index ; Other metabolic disorders</subject><ispartof>European journal of clinical investigation, 2005-04, Vol.35 (4), p.265-270</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Apr 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5280-24e55d39ca5b0e1ebf7b98a77669cda5bab62798d1c16340f7236e68c373e21c3</citedby><cites>FETCH-LOGICAL-c5280-24e55d39ca5b0e1ebf7b98a77669cda5bab62798d1c16340f7236e68c373e21c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2362.2005.01490.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2362.2005.01490.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16712770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15816996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bo, S.</creatorcontrib><creatorcontrib>Gambino, R.</creatorcontrib><creatorcontrib>Uberti, B.</creatorcontrib><creatorcontrib>Mangiameli, M. P.</creatorcontrib><creatorcontrib>Colosso, G.</creatorcontrib><creatorcontrib>Repetti, E.</creatorcontrib><creatorcontrib>Gentile, L.</creatorcontrib><creatorcontrib>Cassader, M.</creatorcontrib><creatorcontrib>Pagano, G. F.</creatorcontrib><title>Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects.
Design Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia.
Results In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile.
Conclusions The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>General aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - diagnosis</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>normal body mass index</subject><subject>Other metabolic disorders</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O3DAURi1UBFPoKyALqd0l-GdsxwtUoSkdkEbAAtSl5Tg3wiGTUDtpZ96-TmcEUlf1xtb1-a6vD0KYkpymddHklEuRMS5ZzggROaFzTfLNAZq9XXxAM5LKGdOKHaOPMTaEkIJydoSOqSio1FrO0NO3HiJeZAGsG_wvwK-hH8B32FfQDb7eYovjWLrWd97ZFq9hsGXfeocrH8FGwIl9BtsOz9sJbMAN8espOqxtG-HTfj9BT9-vHxc32ep-ebu4WmVOsIJkbA5CVFw7K0oCFMpalbqwSkmpXZWKtpRM6aKijko-J7VKHwNZOK44MOr4Cfqy65um_jlCHMzaRwdtazvox2ikUlTNBU3g-T9g04-hS7MZqjVl6RmWoGIHudDHGKA2r8GvbdgaSszk3TRm0msmvWbybv56N5sUPdv3H8s1VO_BvegEfN4DNiaPdbCd8_Gdk4oypUjiLnfcb9_C9r8HMNeL2-mU8tku7-MAm7e8DS9JBlfC_LhbmrsHtlrepD6S_wHaz6wa</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Bo, S.</creator><creator>Gambino, R.</creator><creator>Uberti, B.</creator><creator>Mangiameli, M. P.</creator><creator>Colosso, G.</creator><creator>Repetti, E.</creator><creator>Gentile, L.</creator><creator>Cassader, M.</creator><creator>Pagano, G. F.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?</title><author>Bo, S. ; Gambino, R. ; Uberti, B. ; Mangiameli, M. P. ; Colosso, G. ; Repetti, E. ; Gentile, L. ; Cassader, M. ; Pagano, G. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5280-24e55d39ca5b0e1ebf7b98a77669cda5bab62798d1c16340f7236e68c373e21c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>General aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - diagnosis</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>normal body mass index</topic><topic>Other metabolic disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bo, S.</creatorcontrib><creatorcontrib>Gambino, R.</creatorcontrib><creatorcontrib>Uberti, B.</creatorcontrib><creatorcontrib>Mangiameli, M. P.</creatorcontrib><creatorcontrib>Colosso, G.</creatorcontrib><creatorcontrib>Repetti, E.</creatorcontrib><creatorcontrib>Gentile, L.</creatorcontrib><creatorcontrib>Cassader, M.</creatorcontrib><creatorcontrib>Pagano, G. F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bo, S.</au><au>Gambino, R.</au><au>Uberti, B.</au><au>Mangiameli, M. P.</au><au>Colosso, G.</au><au>Repetti, E.</au><au>Gentile, L.</au><au>Cassader, M.</au><au>Pagano, G. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does C-reactive protein identify a subclinical metabolic disease in healthy subjects?</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2005-04</date><risdate>2005</risdate><volume>35</volume><issue>4</issue><spage>265</spage><epage>270</epage><pages>265-270</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background Highly sensitive C‐reactive protein (hs‐CRP) levels are significant predictors of subsequent diabetes and metabolic syndrome (MS). Owing the strong correlations between components of the MS and obesity with hs‐CRP levels, previous studies about the associations of hs‐CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects.
Design Our aim was to evaluate the associations between hs‐CRP levels and fasting insulin and insulin resistance (evaluated by the Homeostasis Model Assessment: HOMA IR) in a subgroup of subjects with normal body mass index (BMI) and without any metabolic abnormalities. Out of a cohort of 1658 middle‐aged subjects, representative of the local sanitary districts of the province of Asti (north‐western Italy) enrolled for metabolic screening: 241 (14·5%) showed normal BMI, glucose tolerance, blood pressure and waist values and no dyslipidaemia.
Results In this subgroup of subjects, those with hs‐CRP levels ≥ 3 mg L−1 showed significantly higher median insulin and HOMA‐IR values (respectively: 20·4 vs. 6·0 pmol L−1, and 0·8 vs. 0·2 µU mL−1× mmol L−1). In a multiple regression model, insulin and insulin resistance remained significantly and independently related to hs‐CRP levels, after adjustments for age, sex, BMI, waist, alcohol consumption, level of physical activity and smoking habits. Very few individuals within lower fasting insulin quartiles showed hs‐CRP values ≥ 3 mg L−1 when compared with approximately 60% of those within the highest quartile.
Conclusions The novel finding is that a state of low‐grade systemic inflammation is present in normal BMI subjects who show subclinical insulin resistance but no other metabolic abnormalities.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15816996</pmid><doi>10.1111/j.1365-2362.2005.01490.x</doi><tpages>6</tpages></addata></record> |
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subjects | Biological and medical sciences Body Mass Index C-reactive protein C-Reactive Protein - analysis Cohort Studies Female General aspects Homeostasis Humans Insulin - blood Insulin Resistance Male Medical sciences Metabolic diseases metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - diagnosis Middle Aged Miscellaneous normal body mass index Other metabolic disorders |
title | Does C-reactive protein identify a subclinical metabolic disease in healthy subjects? |
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