Production of GMP-grade radioactive holmium loaded poly( l-lactic acid) microspheres for clinical application

Radioactive holmium-166 loaded poly( l-lactic acid) microspheres are promising systems for the treatment of liver malignancies. The microspheres are loaded with holmium acetylacetonate (HoAcAc) and prepared by a solvent evaporation method. After preparation, the microspheres (Ho-PLLA-MS) are activat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of pharmaceutics 2006-03, Vol.311 (1), p.69-74
Hauptverfasser:	Zielhuis, S.W., Nijsen, J.F.W., de Roos, R., Krijger, G.C., van Rijk, P.P., Hennink, W.E., van het Schip, A.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brachytherapy - methods CFU Endotoxins General pharmacology GMP Guidelines as Topic Holmium Holmium - chemistry Holmium - radiation effects Lactic Acid - chemistry Lactic Acid - radiation effects Medical sciences Microspheres Neutrons Nuclear Reactors Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLLA Polyesters Polymers - chemistry Polymers - radiation effects Quality Control Radioisotopes Stability Surface Properties Technology, Pharmaceutical - methods Technology, Pharmaceutical - standards Temperature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!