Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack
Background: Exactly what role does tumor-derived Fas ligand (FasL) play in cancer: maintaining the immune privilege site or inducing a pro-inflammatory effect? One possible hypothesis is that tumor-associated macrophages (TAM) act as the mediator that enables apoptosis of anti-tumor immune cells wit...
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| Veröffentlicht in: | Anticancer research 2005-01, Vol.25 (1B), p.463-470 |
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| creator | OHNO, Satoshi INAGAWA, Hiroyuki NAGASUE, Naofumi DHAR, Dipok Kumar FUJII, Toshiyuki UEDA, Shuhei TACHIBANA, Mitsuo OHNO, Yumiko SUZUKI, Nobutaka INOUE, Masaki SOMA, Gen-Ichiro |
| description | Background: Exactly what role does tumor-derived Fas ligand (FasL) play in cancer: maintaining the immune privilege site or
inducing a pro-inflammatory effect? One possible hypothesis is that tumor-associated macrophages (TAM) act as the mediator
that enables apoptosis of anti-tumor immune cells without FasL-related inflammation. We have evaluated the tumor FasL expression
and TAM along the tumor margin and/or in cancer stroma, and their impact on the infiltration of immune-competent cells into
the tumor nest. Patients and Methods: Tissue specimens from consecutive 84 advanced gastric carcinoma patients, who had undergone
a curative resection, were evaluated for TAM (CD68+ cells), tumor FasL expression and immune status (CD8+ T cells). Results:
A high number of TAM significantly correlated with lymph node metastasis, intestinal type tumor and FasL expression. Although
TAM had a tendency for an inverse correlation with the number of CD8+ T cells within the tumor nest (nest CD8) (p=0.0592),
there was no correlation between FasL expression and nest CD8 (p=0.2158). This inverse association was found to be stronger
in cases with both FasL-positive and high TAM tumors than in others (p=0.0139). The combination parameter of FasL-positive
and high TAM became an independent prognostic factor in Cox's multivariate analysis, along with the pT status, nest CD8 and
tumor cell apoptosis. Conclusion: We suggest that TAM works harmoniously with tumor-derived FasL and serves as a barrier against
the infiltration of CD8+ T cells into the cancer nest. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67716373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67716373</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-fef3b90ca00be583bc509c562175ce107003cc38dde7aea4d4978bddfe39814a3</originalsourceid><addsrcrecordid>eNpF0FFLwzAQB_AiipvTryB5UfShkDRN0vo2h5uDDUHmc7mm1zXaNjVpFb-9hU18uof78efufxJMmUpZqASnp8GURoKGilIxCS68f6dUyjTh58GEiYRJyfg08K-2RmJLshsa60Lw3moDPRZkC9rZroI9enK3m2_viWnJvPiCVo_bFfjeGU0W4LRpbQMPZFchWTcd6J7YlizBb8IGi0PYwg5tjw76HvTHZXBWQu3x6jhnwdvyabd4Djcvq_VivgmrSKZ9WGLJ85RqoDRHkfBcC5pqISOmhEZGx8e41jwpClSAEBdxqpK8KErkacJi4LPg9pDbOfs5oO-zxniNdQ0t2sFnUikmueIjvD7CIR9PzjpnGnA_2V9NI7g5AvAa6tKNJRj_76SUEVfq31VmX30bh5lvoK7HWJ6Bi0TGHrNYcv4LfZZ-sA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67716373</pqid></control><display><type>article</type><title>Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>OHNO, Satoshi ; INAGAWA, Hiroyuki ; NAGASUE, Naofumi ; DHAR, Dipok Kumar ; FUJII, Toshiyuki ; UEDA, Shuhei ; TACHIBANA, Mitsuo ; OHNO, Yumiko ; SUZUKI, Nobutaka ; INOUE, Masaki ; SOMA, Gen-Ichiro</creator><creatorcontrib>OHNO, Satoshi ; INAGAWA, Hiroyuki ; NAGASUE, Naofumi ; DHAR, Dipok Kumar ; FUJII, Toshiyuki ; UEDA, Shuhei ; TACHIBANA, Mitsuo ; OHNO, Yumiko ; SUZUKI, Nobutaka ; INOUE, Masaki ; SOMA, Gen-Ichiro</creatorcontrib><description>Background: Exactly what role does tumor-derived Fas ligand (FasL) play in cancer: maintaining the immune privilege site or
inducing a pro-inflammatory effect? One possible hypothesis is that tumor-associated macrophages (TAM) act as the mediator
that enables apoptosis of anti-tumor immune cells without FasL-related inflammation. We have evaluated the tumor FasL expression
and TAM along the tumor margin and/or in cancer stroma, and their impact on the infiltration of immune-competent cells into
the tumor nest. Patients and Methods: Tissue specimens from consecutive 84 advanced gastric carcinoma patients, who had undergone
a curative resection, were evaluated for TAM (CD68+ cells), tumor FasL expression and immune status (CD8+ T cells). Results:
A high number of TAM significantly correlated with lymph node metastasis, intestinal type tumor and FasL expression. Although
TAM had a tendency for an inverse correlation with the number of CD8+ T cells within the tumor nest (nest CD8) (p=0.0592),
there was no correlation between FasL expression and nest CD8 (p=0.2158). This inverse association was found to be stronger
in cases with both FasL-positive and high TAM tumors than in others (p=0.0139). The combination parameter of FasL-positive
and high TAM became an independent prognostic factor in Cox's multivariate analysis, along with the pT status, nest CD8 and
tumor cell apoptosis. Conclusion: We suggest that TAM works harmoniously with tumor-derived FasL and serves as a barrier against
the infiltration of CD8+ T cells into the cancer nest.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 15816613</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, CD - biosynthesis ; Antigens, CD34 - biosynthesis ; Antigens, Differentiation, Myelomonocytic - biosynthesis ; Apoptosis ; Biological and medical sciences ; CD8 Antigens - biosynthesis ; CD8-Positive T-Lymphocytes - metabolism ; Fas Ligand Protein ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Inflammation ; Macrophages - metabolism ; Male ; Medical sciences ; Membrane Glycoproteins - metabolism ; Microcirculation ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasms - metabolism ; Neovascularization, Pathologic ; Prognosis ; Recurrence ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Time Factors ; Tumors</subject><ispartof>Anticancer research, 2005-01, Vol.25 (1B), p.463-470</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16662377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15816613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OHNO, Satoshi</creatorcontrib><creatorcontrib>INAGAWA, Hiroyuki</creatorcontrib><creatorcontrib>NAGASUE, Naofumi</creatorcontrib><creatorcontrib>DHAR, Dipok Kumar</creatorcontrib><creatorcontrib>FUJII, Toshiyuki</creatorcontrib><creatorcontrib>UEDA, Shuhei</creatorcontrib><creatorcontrib>TACHIBANA, Mitsuo</creatorcontrib><creatorcontrib>OHNO, Yumiko</creatorcontrib><creatorcontrib>SUZUKI, Nobutaka</creatorcontrib><creatorcontrib>INOUE, Masaki</creatorcontrib><creatorcontrib>SOMA, Gen-Ichiro</creatorcontrib><title>Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Exactly what role does tumor-derived Fas ligand (FasL) play in cancer: maintaining the immune privilege site or
inducing a pro-inflammatory effect? One possible hypothesis is that tumor-associated macrophages (TAM) act as the mediator
that enables apoptosis of anti-tumor immune cells without FasL-related inflammation. We have evaluated the tumor FasL expression
and TAM along the tumor margin and/or in cancer stroma, and their impact on the infiltration of immune-competent cells into
the tumor nest. Patients and Methods: Tissue specimens from consecutive 84 advanced gastric carcinoma patients, who had undergone
a curative resection, were evaluated for TAM (CD68+ cells), tumor FasL expression and immune status (CD8+ T cells). Results:
A high number of TAM significantly correlated with lymph node metastasis, intestinal type tumor and FasL expression. Although
TAM had a tendency for an inverse correlation with the number of CD8+ T cells within the tumor nest (nest CD8) (p=0.0592),
there was no correlation between FasL expression and nest CD8 (p=0.2158). This inverse association was found to be stronger
in cases with both FasL-positive and high TAM tumors than in others (p=0.0139). The combination parameter of FasL-positive
and high TAM became an independent prognostic factor in Cox's multivariate analysis, along with the pT status, nest CD8 and
tumor cell apoptosis. Conclusion: We suggest that TAM works harmoniously with tumor-derived FasL and serves as a barrier against
the infiltration of CD8+ T cells into the cancer nest.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Antigens, Differentiation, Myelomonocytic - biosynthesis</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>CD8 Antigens - biosynthesis</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Fas Ligand Protein</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Nick-End Labeling</subject><subject>Inflammation</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasms - metabolism</subject><subject>Neovascularization, Pathologic</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0FFLwzAQB_AiipvTryB5UfShkDRN0vo2h5uDDUHmc7mm1zXaNjVpFb-9hU18uof78efufxJMmUpZqASnp8GURoKGilIxCS68f6dUyjTh58GEiYRJyfg08K-2RmJLshsa60Lw3moDPRZkC9rZroI9enK3m2_viWnJvPiCVo_bFfjeGU0W4LRpbQMPZFchWTcd6J7YlizBb8IGi0PYwg5tjw76HvTHZXBWQu3x6jhnwdvyabd4Djcvq_VivgmrSKZ9WGLJ85RqoDRHkfBcC5pqISOmhEZGx8e41jwpClSAEBdxqpK8KErkacJi4LPg9pDbOfs5oO-zxniNdQ0t2sFnUikmueIjvD7CIR9PzjpnGnA_2V9NI7g5AvAa6tKNJRj_76SUEVfq31VmX30bh5lvoK7HWJ6Bi0TGHrNYcv4LfZZ-sA</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>OHNO, Satoshi</creator><creator>INAGAWA, Hiroyuki</creator><creator>NAGASUE, Naofumi</creator><creator>DHAR, Dipok Kumar</creator><creator>FUJII, Toshiyuki</creator><creator>UEDA, Shuhei</creator><creator>TACHIBANA, Mitsuo</creator><creator>OHNO, Yumiko</creator><creator>SUZUKI, Nobutaka</creator><creator>INOUE, Masaki</creator><creator>SOMA, Gen-Ichiro</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack</title><author>OHNO, Satoshi ; INAGAWA, Hiroyuki ; NAGASUE, Naofumi ; DHAR, Dipok Kumar ; FUJII, Toshiyuki ; UEDA, Shuhei ; TACHIBANA, Mitsuo ; OHNO, Yumiko ; SUZUKI, Nobutaka ; INOUE, Masaki ; SOMA, Gen-Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-fef3b90ca00be583bc509c562175ce107003cc38dde7aea4d4978bddfe39814a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Antigens, Differentiation, Myelomonocytic - biosynthesis</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>CD8 Antigens - biosynthesis</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Fas Ligand Protein</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Nick-End Labeling</topic><topic>Inflammation</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasms - metabolism</topic><topic>Neovascularization, Pathologic</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OHNO, Satoshi</creatorcontrib><creatorcontrib>INAGAWA, Hiroyuki</creatorcontrib><creatorcontrib>NAGASUE, Naofumi</creatorcontrib><creatorcontrib>DHAR, Dipok Kumar</creatorcontrib><creatorcontrib>FUJII, Toshiyuki</creatorcontrib><creatorcontrib>UEDA, Shuhei</creatorcontrib><creatorcontrib>TACHIBANA, Mitsuo</creatorcontrib><creatorcontrib>OHNO, Yumiko</creatorcontrib><creatorcontrib>SUZUKI, Nobutaka</creatorcontrib><creatorcontrib>INOUE, Masaki</creatorcontrib><creatorcontrib>SOMA, Gen-Ichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OHNO, Satoshi</au><au>INAGAWA, Hiroyuki</au><au>NAGASUE, Naofumi</au><au>DHAR, Dipok Kumar</au><au>FUJII, Toshiyuki</au><au>UEDA, Shuhei</au><au>TACHIBANA, Mitsuo</au><au>OHNO, Yumiko</au><au>SUZUKI, Nobutaka</au><au>INOUE, Masaki</au><au>SOMA, Gen-Ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>25</volume><issue>1B</issue><spage>463</spage><epage>470</epage><pages>463-470</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Exactly what role does tumor-derived Fas ligand (FasL) play in cancer: maintaining the immune privilege site or
inducing a pro-inflammatory effect? One possible hypothesis is that tumor-associated macrophages (TAM) act as the mediator
that enables apoptosis of anti-tumor immune cells without FasL-related inflammation. We have evaluated the tumor FasL expression
and TAM along the tumor margin and/or in cancer stroma, and their impact on the infiltration of immune-competent cells into
the tumor nest. Patients and Methods: Tissue specimens from consecutive 84 advanced gastric carcinoma patients, who had undergone
a curative resection, were evaluated for TAM (CD68+ cells), tumor FasL expression and immune status (CD8+ T cells). Results:
A high number of TAM significantly correlated with lymph node metastasis, intestinal type tumor and FasL expression. Although
TAM had a tendency for an inverse correlation with the number of CD8+ T cells within the tumor nest (nest CD8) (p=0.0592),
there was no correlation between FasL expression and nest CD8 (p=0.2158). This inverse association was found to be stronger
in cases with both FasL-positive and high TAM tumors than in others (p=0.0139). The combination parameter of FasL-positive
and high TAM became an independent prognostic factor in Cox's multivariate analysis, along with the pT status, nest CD8 and
tumor cell apoptosis. Conclusion: We suggest that TAM works harmoniously with tumor-derived FasL and serves as a barrier against
the infiltration of CD8+ T cells into the cancer nest.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>15816613</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigens, CD - biosynthesis Antigens, CD34 - biosynthesis Antigens, Differentiation, Myelomonocytic - biosynthesis Apoptosis Biological and medical sciences CD8 Antigens - biosynthesis CD8-Positive T-Lymphocytes - metabolism Fas Ligand Protein Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry In Situ Nick-End Labeling Inflammation Macrophages - metabolism Male Medical sciences Membrane Glycoproteins - metabolism Microcirculation Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasms - metabolism Neovascularization, Pathologic Prognosis Recurrence Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Tumors |
| title | Role of Tumor-associated Macrophages (TAM) in Advanced Gastric Carcinoma: The Impact on FasL-mediated Counterattack |
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