The MYCN enigma : Significance of MYCN expression in neuroblastoma

MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prog...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-03, Vol.66 (5), p.2826-2833
Hauptverfasser:	TANG, Xao X, HUAQING ZHAO, BING KUNG, KIM, David Y, HICKS, Sakeenah L, COHN, Susan L, CHEUNG, Nai-Kong, SEEGER, Robert C, EVANS, Audrey E, IKEGAKI, Naohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cohort Studies Gene Amplification Humans Medical sciences N-Myc Proto-Oncogene Protein Neoplasm Staging Neuroblastoma - genetics Neuroblastoma - metabolism Neuroblastoma - pathology Neurology Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Oncogene Proteins - biosynthesis Oncogene Proteins - genetics Pharmacology. Drug treatments Prognosis Receptor, trkA - biosynthesis Receptor, trkA - genetics Reverse Transcriptase Polymerase Chain Reaction Tumors Tumors of the nervous system. Phacomatoses
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