Emergence of a new human adenovirus type 4 (Ad4) genotype: Identification of a novel inverted terminal repeated (ITR) sequence from majority of Ad4 isolates from US military recruits
Ad4 is the principal etiological agent of acute respiratory disease (ARD) in the US military. Discovery of the novel 208 bp inverted terminal repeated (ITR) sequence from a recent Ad4 Jax78 field isolate was totally distinct from the analogous 116 bp ITR of Ad4 prototype. To investigate the origin a...
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| Veröffentlicht in: | Journal of clinical virology 2006-04, Vol.35 (4), p.381-387 |
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| creator | Houng, Huo-Shu H. Clavio, Sarah Graham, Katherine Kuschner, Robert Sun, Wellington Russell, Kevin L. Binn, Leonard N. |
| description | Ad4 is the principal etiological agent of acute respiratory disease (ARD) in the US military. Discovery of the novel 208
bp inverted terminal repeated (ITR) sequence from a recent Ad4 Jax78 field isolate was totally distinct from the analogous 116
bp ITR of Ad4 prototype.
To investigate the origin and distribution of the novel Ad4 ITR sequence from ARD infections.
Direct sequencing of ligated Ad ITR termini.
The new Ad4 ITR was highly homologous with the ITRs of human Ad subgroup B. The left post-ITR region of Ad4 Jax78 was found to be highly homologous to the corresponding region of subgroup B Ads: 81% for Ad11 and 98% for Ad3 and Ad7. The right post-ITR region of Ad4 Jax78 contained a truncated classic ITR of the Ad4 prototype.
The Ad4 Jax78 ITR most likely evolved from Ad4 prototype by substituting the Ad4 prototype ITR with the subgroup B Ads ITR. The ITR-based PCR assays developed from this study can be used to distinguish the new Ad4 genotype from the classical Ad4 prototype. The new Ad4 genotype was first detected in 1976 from Georgia, USA, and is the main causative agent of ARD infections in US military population. |
| doi_str_mv | 10.1016/j.jcv.2005.11.008 |
| format | Article |
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bp inverted terminal repeated (ITR) sequence from a recent Ad4 Jax78 field isolate was totally distinct from the analogous 116
bp ITR of Ad4 prototype.
To investigate the origin and distribution of the novel Ad4 ITR sequence from ARD infections.
Direct sequencing of ligated Ad ITR termini.
The new Ad4 ITR was highly homologous with the ITRs of human Ad subgroup B. The left post-ITR region of Ad4 Jax78 was found to be highly homologous to the corresponding region of subgroup B Ads: 81% for Ad11 and 98% for Ad3 and Ad7. The right post-ITR region of Ad4 Jax78 contained a truncated classic ITR of the Ad4 prototype.
The Ad4 Jax78 ITR most likely evolved from Ad4 prototype by substituting the Ad4 prototype ITR with the subgroup B Ads ITR. The ITR-based PCR assays developed from this study can be used to distinguish the new Ad4 genotype from the classical Ad4 prototype. The new Ad4 genotype was first detected in 1976 from Georgia, USA, and is the main causative agent of ARD infections in US military population.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2005.11.008</identifier><identifier>PMID: 16406799</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Ad-associated ARD ; Adenovirus Infections, Human - virology ; Adenoviruses, Human - classification ; Adenoviruses, Human - genetics ; Adenoviruses, Human - isolation & purification ; Base Sequence ; Biological and medical sciences ; Cell Line, Tumor ; Fundamental and applied biological sciences. Psychology ; Genotype ; Human adenovirus ; Human adenovirus type 4 ; Human viral diseases ; Humans ; Infectious diseases ; Inverted terminal repeat (ITR) ; Medical sciences ; Microbiology ; Military Personnel ; Miscellaneous ; Molecular Sequence Data ; New Ad4 genotype ; Polymerase Chain Reaction - methods ; Sequence Analysis, DNA ; Terminal binding protein ; Terminal Repeat Sequences - genetics ; United States ; Viral diseases ; Virology</subject><ispartof>Journal of clinical virology, 2006-04, Vol.35 (4), p.381-387</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-276f22b84abbe29835df4b5dd0534f872e09d8281850e4918ad8a46418ae21f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2005.11.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17897080$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16406799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houng, Huo-Shu H.</creatorcontrib><creatorcontrib>Clavio, Sarah</creatorcontrib><creatorcontrib>Graham, Katherine</creatorcontrib><creatorcontrib>Kuschner, Robert</creatorcontrib><creatorcontrib>Sun, Wellington</creatorcontrib><creatorcontrib>Russell, Kevin L.</creatorcontrib><creatorcontrib>Binn, Leonard N.</creatorcontrib><title>Emergence of a new human adenovirus type 4 (Ad4) genotype: Identification of a novel inverted terminal repeated (ITR) sequence from majority of Ad4 isolates from US military recruits</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>Ad4 is the principal etiological agent of acute respiratory disease (ARD) in the US military. Discovery of the novel 208
bp inverted terminal repeated (ITR) sequence from a recent Ad4 Jax78 field isolate was totally distinct from the analogous 116
bp ITR of Ad4 prototype.
To investigate the origin and distribution of the novel Ad4 ITR sequence from ARD infections.
Direct sequencing of ligated Ad ITR termini.
The new Ad4 ITR was highly homologous with the ITRs of human Ad subgroup B. The left post-ITR region of Ad4 Jax78 was found to be highly homologous to the corresponding region of subgroup B Ads: 81% for Ad11 and 98% for Ad3 and Ad7. The right post-ITR region of Ad4 Jax78 contained a truncated classic ITR of the Ad4 prototype.
The Ad4 Jax78 ITR most likely evolved from Ad4 prototype by substituting the Ad4 prototype ITR with the subgroup B Ads ITR. The ITR-based PCR assays developed from this study can be used to distinguish the new Ad4 genotype from the classical Ad4 prototype. The new Ad4 genotype was first detected in 1976 from Georgia, USA, and is the main causative agent of ARD infections in US military population.</description><subject>Ad-associated ARD</subject><subject>Adenovirus Infections, Human - virology</subject><subject>Adenoviruses, Human - classification</subject><subject>Adenoviruses, Human - genetics</subject><subject>Adenoviruses, Human - isolation & purification</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Human adenovirus</subject><subject>Human adenovirus type 4</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inverted terminal repeat (ITR)</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Military Personnel</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>New Ad4 genotype</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Sequence Analysis, DNA</subject><subject>Terminal binding protein</subject><subject>Terminal Repeat Sequences - genetics</subject><subject>United States</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhSMEoj_wAGyQN6B2kWA7TuyUVVUVuFIlJGjXlmNPwFESX2wn6L4Yz1eHG6k7WHk0882Z8Zwse0NwQTCpP_RFr5eCYlwVhBQYi2fZKRG8zKum5s9TXIo6r6uSnmRnIfQYk6pk_GV2QmqGa940p9mf2xH8D5g0INchhSb4jX7Oo5qQMjC5xfo5oHjYA2Lo4tqwS5Rgtyau0C4R0XZWq2jdtPW7BQZkpwV8BIMi-NFOakAe9qDWzMXu_tslCvBr_ju0825Eo-qdt_GwSqQZyAY3JDgcqw_f0WgHG5U_JBntZxvDq-xFp4YAr7f3PHv4dHt_8yW_-_p5d3N9l2tGaMwprztKW8FU2wJtRFmZjrWVMTgdohOcAm6MoIKICgNriFBGKFazFAAlnSjPs_dH3b13aeMQ5WiDhmFQE7g5yJpzUlVN9V-QcIKFoDiB5Ahq70Lw0Mm9t2P6myRYrq7KXiZX5eqqJEQmV1PP2018bkcwTx2bjQl4twEqaDV0Xk3ahieOi4ZjsQ7_eOQg3Wyx4GXQdvXB2HTZKI2z_1jjEVj0wLs</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Houng, Huo-Shu H.</creator><creator>Clavio, Sarah</creator><creator>Graham, Katherine</creator><creator>Kuschner, Robert</creator><creator>Sun, Wellington</creator><creator>Russell, Kevin L.</creator><creator>Binn, Leonard N.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Emergence of a new human adenovirus type 4 (Ad4) genotype: Identification of a novel inverted terminal repeated (ITR) sequence from majority of Ad4 isolates from US military recruits</title><author>Houng, Huo-Shu H. ; Clavio, Sarah ; Graham, Katherine ; Kuschner, Robert ; Sun, Wellington ; Russell, Kevin L. ; Binn, Leonard N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-276f22b84abbe29835df4b5dd0534f872e09d8281850e4918ad8a46418ae21f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Ad-associated ARD</topic><topic>Adenovirus Infections, Human - virology</topic><topic>Adenoviruses, Human - classification</topic><topic>Adenoviruses, Human - genetics</topic><topic>Adenoviruses, Human - isolation & purification</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Human adenovirus</topic><topic>Human adenovirus type 4</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inverted terminal repeat (ITR)</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Military Personnel</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>New Ad4 genotype</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Sequence Analysis, DNA</topic><topic>Terminal binding protein</topic><topic>Terminal Repeat Sequences - genetics</topic><topic>United States</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houng, Huo-Shu H.</creatorcontrib><creatorcontrib>Clavio, Sarah</creatorcontrib><creatorcontrib>Graham, Katherine</creatorcontrib><creatorcontrib>Kuschner, Robert</creatorcontrib><creatorcontrib>Sun, Wellington</creatorcontrib><creatorcontrib>Russell, Kevin L.</creatorcontrib><creatorcontrib>Binn, Leonard N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houng, Huo-Shu H.</au><au>Clavio, Sarah</au><au>Graham, Katherine</au><au>Kuschner, Robert</au><au>Sun, Wellington</au><au>Russell, Kevin L.</au><au>Binn, Leonard N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emergence of a new human adenovirus type 4 (Ad4) genotype: Identification of a novel inverted terminal repeated (ITR) sequence from majority of Ad4 isolates from US military recruits</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>35</volume><issue>4</issue><spage>381</spage><epage>387</epage><pages>381-387</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Ad4 is the principal etiological agent of acute respiratory disease (ARD) in the US military. Discovery of the novel 208
bp inverted terminal repeated (ITR) sequence from a recent Ad4 Jax78 field isolate was totally distinct from the analogous 116
bp ITR of Ad4 prototype.
To investigate the origin and distribution of the novel Ad4 ITR sequence from ARD infections.
Direct sequencing of ligated Ad ITR termini.
The new Ad4 ITR was highly homologous with the ITRs of human Ad subgroup B. The left post-ITR region of Ad4 Jax78 was found to be highly homologous to the corresponding region of subgroup B Ads: 81% for Ad11 and 98% for Ad3 and Ad7. The right post-ITR region of Ad4 Jax78 contained a truncated classic ITR of the Ad4 prototype.
The Ad4 Jax78 ITR most likely evolved from Ad4 prototype by substituting the Ad4 prototype ITR with the subgroup B Ads ITR. The ITR-based PCR assays developed from this study can be used to distinguish the new Ad4 genotype from the classical Ad4 prototype. The new Ad4 genotype was first detected in 1976 from Georgia, USA, and is the main causative agent of ARD infections in US military population.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16406799</pmid><doi>10.1016/j.jcv.2005.11.008</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of clinical virology, 2006-04, Vol.35 (4), p.381-387 |
| issn | 1386-6532 1873-5967 |
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| subjects | Ad-associated ARD Adenovirus Infections, Human - virology Adenoviruses, Human - classification Adenoviruses, Human - genetics Adenoviruses, Human - isolation & purification Base Sequence Biological and medical sciences Cell Line, Tumor Fundamental and applied biological sciences. Psychology Genotype Human adenovirus Human adenovirus type 4 Human viral diseases Humans Infectious diseases Inverted terminal repeat (ITR) Medical sciences Microbiology Military Personnel Miscellaneous Molecular Sequence Data New Ad4 genotype Polymerase Chain Reaction - methods Sequence Analysis, DNA Terminal binding protein Terminal Repeat Sequences - genetics United States Viral diseases Virology |
| title | Emergence of a new human adenovirus type 4 (Ad4) genotype: Identification of a novel inverted terminal repeated (ITR) sequence from majority of Ad4 isolates from US military recruits |
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