Neurogenic Mechanisms Contribute to Hypertension in Mice With Disruption of the K-Cl Cotransporter KCC3

The neurodegenerative disorder Andermann syndrome is caused by mutations of the K-Cl cotransporter KCC3. Mice with a targeted disruption of the corresponding gene, Slc12a6, reproduce neurodegeneration of the peripheral and central nervous system (CNS) and display arterial hypertension. Kcc3 is expre...

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Veröffentlicht in:	Circulation research 2006-03, Vol.98 (4), p.549-556
Hauptverfasser:	Rust, Marco B, Faulhaber, Jörg, Budack, Mareike K, Pfeffer, Carsten, Maritzen, Tanja, Didié, Michael, Beck, Franz-Xaver, Boettger, Thomas, Schubert, Rudolf, Ehmke, Heimo, Jentsch, Thomas J, Hübner, Christian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - blood Animals Biological and medical sciences Calcium - metabolism Chlorides - metabolism Fundamental and applied biological sciences. Psychology Hypertension - etiology Hypertension - physiopathology Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - metabolism Renin-Angiotensin System - physiology Sympathetic Nervous System - physiology Symporters - physiology Vasoconstriction Vertebrates: cardiovascular system
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