The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice

The degeneration of the basal forebrain cholinergic system plays an important role in cognitive deterioration in aging and Alzheimer's disease. Brain cholinergic neurons and their projections are affected by changes in the circulating levels of estrogens, which exert their effects mainly throug...

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Veröffentlicht in:	The European journal of neuroscience 2005-03, Vol.21 (5), p.1437-1442
Hauptverfasser:	Kalesnykas, Giedrius, Roschier, Ulla, Puoliväli, Jukka, Wang, Jun, Miettinen, Riitta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Age Factors Aging - physiology Alzheimer's disease Amyloid beta-Protein Precursor - genetics Analysis of Variance Animals Cell Count - methods Choline O-Acetyltransferase - metabolism Estrogen Receptor alpha - metabolism Female Humans Immunohistochemistry - methods medial septum Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Transgenic Mutation Neurons - cytology Neurons - metabolism ovariectomy Ovariectomy - methods Presenilin-1 Septal Nuclei - cytology stereology Subcellular Fractions - metabolism vertical limb of the diagonal band of Broca
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