Hypoxia-inducible factor-1-dependent repression of E-cadherin in von hippel-lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B

A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of function. Renal clear cell carcinoma (RCC) is characterized by loss of function of the von Hippel-Lindau tumor suppressor (VHL), which negatively regulates hypoxia-inducible factor-1 (HIF-1). Loss of E-cadhe...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-03, Vol.66 (5), p.2725-2731
Hauptverfasser:	KRISHNAMACHARY, Balaji, ZAGZAG, David, NAGASAWA, Hideko, RAINEY, Karin, OKUYAMA, Hiroaki, BAEK, Jin H, SEMENZA, Gregg L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Biological and medical sciences Biopsy Cadherins - biosynthesis Cadherins - genetics Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Adhesion - physiology Down-Regulation Epithelial Cells - pathology Gene Expression Regulation, Neoplastic Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Homeodomain Proteins - physiology Humans Hypoxia-Inducible Factor 1 - biosynthesis Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - physiology Immunohistochemistry Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Medical sciences Mesoderm - pathology Nephrology. Urinary tract diseases Pharmacology. Drug treatments Repressor Proteins - biosynthesis Repressor Proteins - genetics Repressor Proteins - physiology RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic Tumors Tumors of the urinary system Von Hippel-Lindau Tumor Suppressor Protein - biosynthesis Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - physiology Zinc Finger E-box Binding Homeobox 2 Zinc Finger E-box-Binding Homeobox 1
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