A Glycoprotein Hormone Expressed in Corticotrophs Exhibits Unique Binding Properties on Thyroid-Stimulating Hormone Receptor

Corticotroph-derived glycoprotein hormone (CGH), also referred to as thyrostimulin, is a noncovalent heterodimer of glycoprotein hormone α 2 (GPHA2) and glycoprotein hormone β 5 (GPHB5). Here, we demonstrate that both subunits of CGH are expressed in the corticotroph cells of the human anterior pitu...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-02, Vol.20 (2), p.414-425
Hauptverfasser:	Okada, Shannon L, Ellsworth, Jeff L, Durnam, Diane M, Haugen, Harald S, Holloway, James L, Kelley, Merideth L, Lewis, Katherine E, Ren, Hongping, Sheppard, Paul O, Storey, Harold M, Waggie, Kimberly S, Wolf, Anitra C, Yao, Lena Y, Webster, Philippa J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Binding, Competitive CHO Cells Cricetinae Cricetulus Glycoproteins - analysis Glycoproteins - genetics Glycoproteins - metabolism Glycoproteins - pharmacology Humans Hypertrophy Male Mice Mice, Transgenic Peptide Hormones - analysis Peptide Hormones - metabolism Pituitary Gland, Anterior - chemistry Pituitary Gland, Anterior - metabolism Receptors, Thyrotropin - metabolism Retina - chemistry Retina - metabolism Skin - chemistry Skin - metabolism Testis - chemistry Testis - metabolism Thyroid Gland - drug effects Thyroid Gland - pathology Thyroxine - blood Tissue Distribution
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