Recognition of Human Cytomegalovirus by Human Primary Immunoglobulins Identifies an Innate Foundation to an Adaptive Immune Response

Most primates, including humans, are chronically infected with cospecifically evolved, potentially pathogenic CMV. Abs that bind a 10-aa linear epitope (antigenic determinant 2 site 1) within the extracellular domain of human CMV glycoprotein B neutralize viral infectivity. In this study, we show th...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-04, Vol.174 (8), p.4768-4778
Hauptverfasser:	McLean, Gary R, Olsen, Ole A, Watt, Ian N, Rathanaswami, P, Leslie, Kevin B, Babcook, John S, Schrader, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Amino Acid Sequence Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - metabolism Antigens, Viral - genetics Base Sequence Codon - genetics Cytomegalovirus - immunology DNA, Complementary - genetics Human cytomegalovirus Humans Immunity, Innate Immunoglobulin Heavy Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin Variable Region - genetics Immunoglobulins - chemistry Immunoglobulins - genetics Immunoglobulins - metabolism In Vitro Techniques Molecular Sequence Data Peptide Fragments - genetics Peptide Fragments - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Sequence Homology, Amino Acid Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology
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