Amplicon DNA Melting Analysis for Mutation Scanning and Genotyping: Cross-Platform Comparison of Instruments and Dyes

DNA melting analysis for genotyping and mutation scanning of PCR products by use of high-resolution instruments with special "saturation" dyes has recently been reported. The comparative performance of other instruments and dyes has not been evaluated. A 110-bp fragment of the beta-globin...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2006-03, Vol.52 (3), p.494-503
Hauptverfasser:	Herrmann, Mark G, Durtschi, Jacob D, Bromley, L. Kathryn, Wittwer, Carl T, Voelkerding, Karl V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Deoxyribonucleic acid DNA DNA - genetics DNA Mutational Analysis - instrumentation DNA Mutational Analysis - methods Dyes Fluorescent Dyes Fundamental and applied biological sciences. Psychology Genotype Genotypes Globins - genetics Investigative techniques, diagnostic techniques (general aspects) Medical sciences Melting Mutation Organic Chemicals Polymerase Chain Reaction - instrumentation Polymerase Chain Reaction - methods
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