Langerhans Cells Stimulated by Mechanical Stress Are Susceptible to Measles Virus Infection

Objective: Measles virus (MV) first infects the human respiratory tract, but the initial target cells are unknown. We examined whether MV infects Langerhans cell-like dendritic cells (LCs) generated from CD14 + monocytes in the presence of GM-CSF, IL-4, and TGF-β1. Methods: Cultured LCs were establi...

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Veröffentlicht in:	Intervirology 2005-01, Vol.48 (2-3), p.145-152
Hauptverfasser:	Watari, Eiji, Shimizu, Masumi, Takahashi, Hidemi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, CD1 - analysis Antigens, Surface - analysis Cadherins - analysis CD83 Antigen Cells, Cultured Centrifugation Flow Cytometry Giant Cells Glycoproteins - analysis Humans Immunoglobulins - analysis Langerhans Cells - cytology Langerhans Cells - immunology Langerhans Cells - virology Lectins, C-Type - analysis Lymphocyte Activation Mannose-Binding Lectins - analysis Measles virus Measles virus - physiology Membrane Cofactor Protein Membrane Glycoproteins - analysis Microscopy, Fluorescence Nucleocapsid Proteins - biosynthesis Original Paper Receptors, Cell Surface Signaling Lymphocytic Activation Molecule Family Member 1 Stress, Mechanical T-Lymphocytes - immunology
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