STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage

STAT-1 plays a role in mediating stress responses to various stimuli and has also been implied to be a tumour suppressor. Here, we report that STAT-1-deficient cells have defects both in intra-S-phase and G2-M checkpoints in response to DNA damage. Interestingly, STAT-1-deficient cells showed reduce...

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Veröffentlicht in:	Journal of cell science 2005-04, Vol.118 (8), p.1629-1639
Hauptverfasser:	Townsend, Paul A, Cragg, Mark S, Davidson, Sean M, McCormick, James, Barry, Sean, Lawrence, Kevin M, Knight, Richard A, Hubank, Michael, Chen, Phang-Lang, Latchman, David S, Stephanou, Anastasis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cells, Cultured Checkpoint Kinase 2 Chromosomal Proteins, Non-Histone DNA Damage - physiology DNA Repair - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - genetics Genes, cdc - physiology Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction - genetics STAT1 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Tumor Suppressor p53-Binding Protein 1 Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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