Spectrophotometric Determination of Anthracycline Anticancer Agents with Aluminum(III) and Chromazurol S in a Nonionic Surfactant Micellar Medium

A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, th...

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Veröffentlicht in:	Analytical Sciences 2006, Vol.22(2), pp.313-316
Hauptverfasser:	NAKAO, Masahiro, YAMAZAKI, Chikako, TOMINAGA, Hiroshi, YAMAGUCHI, Takako, FUJITA, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum - chemistry Anthracyclines - chemistry Antibiotics, Antineoplastic - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Calibration Chemistry Techniques, Analytical - methods Chemistry, Pharmaceutical - methods Coloring Agents - pharmacology Hydrogen-Ion Concentration Hydroxybenzoates - chemistry Ions Micelles Regression Analysis Spectrophotometry Surface-Active Agents - chemistry
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Beschreibung
Zusammenfassung:	A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 × 105 dm3 mol-1 cm-1 at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 µg ml-1 for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.
ISSN:	0910-6340 1348-2246
DOI:	10.2116/analsci.22.313